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| 題名: | Antihypertensive activity of dl-tetrahydropalmatine, an active alkaloid isolated from the tubers of Corydalis racemosa |
| 作者: | Chu, LH;Hsu, FL;Chueh, FY;Niu, CS;Cheng, JT |
| 貢獻者: | 附設醫院;TAIPEI MED COLL,SCH PHARM,DEPT MED CHEM,TAIPEI 10501,TAIWAN;CHINA MED COLL HOSP,INST CHINESE PHARMACEUT SCI,TAICHUNG 40401,TAIWAN;TZU CHI JR COLL NURSING,PHARMACOL LAB,HUALIEN 97001,TAIWAN;NATL CHENG KUNG UNIV,COLL MED,DEPT PHARMACOL,TAINAN 70101,TAIWAN |
| 日期: | 1996 |
| 上傳時間: | 2010-09-24 14:16:19 (UTC+8) |
| 出版者: | CHINESE CHEM SOC |
| 摘要: | The effect of (-)-epicatechin 4-benzylthioether (EC-BE) on the growth of cultured rat glioma cells was investigated, EC-BE was found to produce a concentration-dependent inhibitory effect on the growth of glioma cells, Inhibition was also observed in samples treated with (-)-epicatechin acetoxymethyl ester (EC-AM), The original compound(-)-epicatechin, which gave rise to EC-AM and EC-BE, failed to produce a similar result, Because both EC-BE and EC-AM are membrane permeable, while (-)-epicatechin is not, the results indicated that the (-)-epicatechin and its derivatives need to be intracellular in order to produce an effect, Moreover, it is demonstrated that EC-BE inhibited the incorporation of [H-3]thymidine into DNA while the uptake of extracellular [H-3]thymidine by glioma cells was not affected, The activities of redox enzymes such as glutathione peroxidase and glutathione reductase were attenuated in cells treated with EC-BE, These data suggest that EC-BE can inhibit the growth of glioma cells by affecting a redox pathway related to the formation of DNA. |
| 關聯: | JOURNAL OF THE CHINESE CHEMICAL SOCIETY 43(6):489-492 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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