DIMINISHED TC-99M HMPAO PULMONARY UPTAKE IN EX-SMOKERS

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Title:	DIMINISHED TC-99M HMPAO PULMONARY UPTAKE IN EX-SMOKERS
Authors:	SHIH, WJ;LEE, JK;COUPAL, J;LAI, YL;GRUNWALD, F;BIERSACK, H
Contributors:	附設醫院;VET ADM MED CTR,LEXINGTON,KY 40511;UNIV KENTUCKY,MED CTR,LEXINGTON,KY;CHINA MED COLL HOSP,TAICHUNG,TAIWAN;NATL TAIWAN UNIV,COLL MED,TAIPEI 10764,TAIWAN;UNIV BONN,W-5300 BONN,GERMANY
Date:	1995
Issue Date:	2010-09-24 14:16:16 (UTC+8)
Publisher:	LIPPINCOTT-RAVEN PUBL
Abstract:	The effects of intracerebroventricular and intrahypothalamic injections of picrotoxin, a GABA antagonist, on gastric acid secretion were studied in perfused stomachs of rats under anesthesia. Injection of picrotoxin into the lateral cerebroventricle inhibited the 2-deoxy-D-glucose-stimulated acid secretion. In experiments of intrahypothalamic injections, picrotoxin produced a significant depression of 2-deoxy-D-glucose-stimulated acid secretion when administered to the ventromedial hypothalamus but not to the lateral hypothalamus. In contrast, picrotoxin produced a definite stimulatory effect on basal acid secretion when injected to the lateral hypothalamus or ventromedial hypothalamus; the stimulatory effect of the injection to the lateral hypothalamus was greater than that of the injection to the ventromedial hypothalamus. These findings indicate that picrotoxin acts centrally, probably hypothalamus, to depress the 2-deoxy-D-glucose-stimulated acid secretion. On the other hand, blockade of GABA activity in the lateral hypothalamus or ventromedial hypothalamus may elicit gastric acid secretion. These results, indicate that central GABAergic mechanism is important in regulating gastric acid secretion in the rat.
Relation:	CLINICAL NUCLEAR MEDICINE 20(9):788-791
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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