Impaired IGF-I signalling of hypertrophic hearts in the developmental phase of hypertension in genetically hypertensive rats

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Title:	Impaired IGF-I signalling of hypertrophic hearts in the developmental phase of hypertension in genetically hypertensive rats
Authors:	Kuo, WW;Chu, CY;Wu, CH;Lin, JA;Liu, JY;Hsieh, YH;Ueng, KC;Lee, SD;Hsieh, DJY;Hsu, HH;Chen, LM;Huang, CY
Contributors:	生命科學院生科系;Chung Shan Med Univ, Inst Biochem, Taichung 402, Taiwan;Chung Shan Med Univ, Sch Appl Chem, Taichung 402, Taiwan;Chung Shan Med Univ, Dept Internal Med, Taichung 402, Taiwan;Chung Shan Med Univ, Dept Phys Therapy, Taichung 402, Taiwan;Chung Shan Med Univ, Dept Med Technol, Taichung 402, Taiwan;Natl Chung Hsing Univ, Dept Vet Med, Taichung 40227, Taiwan;Mackay Mem Hosp, Div Colorectal Surg, Taipei, Taiwan;Armed Forces Taichung Gen Hosp, Taichung, Taiwan;China Med Univ, Dept Biol Sci & Technol, Taichung, Taiwan
Date:	2005
Issue Date:	2010-09-24 14:14:58 (UTC+8)
Publisher:	JOHN WILEY & SONS LTD
Abstract:	Objective To elucidate the pitfalls in the diagnosis of medullary thyroid carcinoma (MTC) by fine needle aspiration cytology (FNAC), and the relationship of cytomorphology to RET proto-oncogene mutations. Study Design Cytomorphology was reviewed in the fine needle aspiration slides of 34 patients with MTC proven by surgery and pathology. Germline or somatic RET proto-oncogene mutations were determined using polymerase chain reaction-based sequencing in 15 of 34 patients, and the relationship to cytomorphology was evaluated. Results Twenty-eight (82.4%) of 34 cases were diagnosed correctly as MTC by FNAC, 3 cases were misdiagnosed as follicular neoplasm and 1 as desmoid, and 2 cases were suspicious for MTC. The main reason for misdiagnosis was overlooking the slight angular shape of the nuclei or atypical changes. In 15 of 34 cases with germline or somatic RET protooncogene mutations determined, 10 cases bad a germline mutation, and 1 had only a somatic mutation. There were 4 cases that had neither germline nor somatic RET protooncogene mutations. Cells with small/round and spindled forms were the predominant findings of codon 918 ATG -> ACG mutation, and cells with small/round and large oval to polygonal forms were the main findings of codon 634 mutations. There were no misdiagnoses in patients with RET proto-oncogene mutations. Conclusion FNAC is a good diagnostic method for MTC. Codon 918 mutation correlates mainly with small/round and spindled cells and codon 634 with small/round, large oval to polygonal forms.
Relation:	CELL BIOCHEMISTRY AND FUNCTION 23(5):325-331
Appears in Collections:	[Department of Biological Science and Technology] Journal articles

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