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http://ir.cmu.edu.tw/ir/handle/310903500/28926
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| 題名: | 17 beta-estradiol reduces cardiac hypertrophy mediated through the up-regulation of PI3K/Akt and the suppression of calcineurin/NF-AT3 signaling pathways in rats |
| 作者: | Wu, CH;Liu, JY;Wu, JP;Hsieh, YH;Liu, CJ;Hwang, JM;Lee, SD;Chen, LM;Chang, MH;Kuo, WW;Shyu, JC;Tsai, JH;Huang, CY |
| 貢獻者: | 生命科學院生科系;Chung Shan Med Univ, Inst Biochem, Taichung 402, Taiwan;China Med Univ, Dept Biol Sci & Technol, Taichung, Taiwan;Chung Shan Med Univ, Sch Appl Chem, Taichung 402, Taiwan;Chung Shan Med Univ, Sch Phys Therapy, Taichung 402, Taiwan;Armed Forces Taichung Gen Hosp, Taichung 402, Taiwan;Chung Shan Med Univ, Inst Physiol, Taichung 402, Taiwan;Fooyin Inst Technol, Dept Nursing, Kaohsiung 831, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 14:14:52 (UTC+8) |
| 出版者: | PERGAMON-ELSEVIER SCIENCE LTD |
| 摘要: | Oxidative stress is one of the major risk factors for coronary artery disease. Ellagic acid is a phenolic compound present in fruits and nuts, and has been found to have antioxidative property. Twenty-four New Zealand white (NZW) rabbits were assigned randomly into four dietary groups. The normal group was fed regular rabbit chow, and the cholesterol group was fed a high fat and cholesterol diet. The ellagic acid (E) group and probucol group were fed the same diet as the cholesterol group plug the addition of 1% (w/w diet) ellagic acid and probucol, respectively. Oxidative stress [as measured by plasma lipids, oxygen free radicals and thiobarbituric acid reactive substances (TBARS)] increased in the cholesterol group compared with the normal group; however, it decreased in the probucol and E groups compared with the cholesterol group. Forty-five percent of the intimal surface of the thoracic aorta was covered with atherosclerotic lesions in the cholesterol group, but only 2-3% was covered in the E and probucol groups. The aortic level of 8-(OH)dG and the expression of caspase-8, caspase-9 and Fas ligand were also suppressed after ellagic acid supplement. These results indicated that ellagic acid could prevent atherosclerosis via suppression of oxidative stress and apoptosis in hyperlipidemic rabbits. (c) 2005 Elsevier Inc. All rights reserved. |
| 關聯: | LIFE SCIENCES 78(4):347-356 |
| 顯示於類別: | [生物科技學系暨碩士班] 期刊論文
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