Effect of inhibition of aloe-emodin on N-acetyltransferase activity and gene expression in human malignant melanoma cells (A375.S2)

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 生命科學院 > 生物科技學系暨碩士班 > 期刊論文 > Item 310903500/28925

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题名:	Effect of inhibition of aloe-emodin on N-acetyltransferase activity and gene expression in human malignant melanoma cells (A375.S2)
作者:	Lin, SY;Yang, JH;Hsia, TC;Lee, JH;Chiu, TH;Wei, YH;Chung, JG
贡献者:	生命科學院生科系;China Med Univ, Sch Biol Sci & Biotechnol, Dept Microbiol, Taichung 400, Taiwan;Hung Kuang Univ, Dept Food & Nutr, Taichung, Taiwan;Chung Shan Med Univ Hosp, Dept Dermatol, Taichung, Taiwan;China Med Univ Hosp, Dept Internal Med, Taichung, Taiwan;China Med Univ Hosp, Dept Surg, Taichung, Taiwan;China Med Univ Hosp, Dept Obstet Gynecol, Taichung, Taiwan;Natl Yang Ming Univ, Dept Biochem & Mol Biol, Taipei, Taiwan
日期:	2005
上传时间:	2010-09-24 14:14:50 (UTC+8)
出版者:	LIPPINCOTT WILLIAMS & WILKINS
摘要:	From the methanolic extract of the leaves of Planchonella duclitan, 2 alpha, 3 alpha, 19 alpha, 23-tetrahydroxy-13,27cyclours-11-en-28-oic acid (1), myrianthic acid (2), 2-hydroxyursolic acid (3), ursolic acid (4), pomolic acid (5), rotundic acid (6), andjacournaric acid (7) were isolated, and their structures were elucidated on the basis of their spectroscopic analysis. Among them, compound 1 was a new cyclopropyl ursane-type triterpenc acid. Additionally, Compounds 4 and 7 showed significant cytotoxicity toward human colorectal carcinoma cell line HT29 and human breast carcinoma cell line MCF-7 with IC50 values ranging from 5.8 +/- 1.4 to 6.5 +/- 1.9 mu M.
關聯:	MELANOMA RESEARCH 15(6):489-494
显示于类别:	[生物科技學系暨碩士班] 期刊論文

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