The molluscan neuropeptide FMRFamide stimulates the release of [14C]acetylcholine from isolated ileal synaptosomal preparations of guinea-pig

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 北港附設醫院 > 期刊論文 > Item 310903500/28921

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题名:	The molluscan neuropeptide FMRFamide stimulates the release of [14C]acetylcholine from isolated ileal synaptosomal preparations of guinea-pig
作者:	CHANG, SS;CHENG, JT
贡献者:	北港附設醫院;NATL CHENG KUNG UNIV,COLL MED,DEPT PHARMACOL,TAINAN 70101,TAIWAN;MA TSU HOSP,CHINA MED COLL,DEPT NEUROL,TAIPEI 65114,TAIWAN
关键词:	FMRFamide;Acetylcholine release;Calcium dependency;Ileal synaptosome;Guinea-pig
日期:	1989
上传时间:	2010-09-24 14:13:59 (UTC+8)
出版者:	ELSEVIER SCI IRELAND LTD
摘要:	FMRFamide stimulated, in a dose-dependent manner, the efflux of [14C]acetylcholine (ACh) from isolated synaptosomes of guinea-pig ileum preloaded with labelled choline. Participation of the cholinergic mechanism and/or substance P was ruled out by the finding that antagonists failed to affect the FMRFamide-induced release of ACh. The ACh-releasing action of FMRFamide was negated by the deletion of calcium ion from the bathing medium and it was also abolished by tetrodotoxin. The results obtained suggest that FMRFamide possesses the ability to induce the release of ACh from enteric synaptosomes of guinea-pig.
關聯:	NEUROSCIENCE RESEARCH 7(1):81-85
显示于类别:	[北港附設醫院] 期刊論文

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