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http://ir.cmu.edu.tw/ir/handle/310903500/28918
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| 題名: | Establishing a prediction model for coronary angiography based on coronary risk factors |
| 作者: | Ma, TC;Jong, GP;Ueng, KC;Chou, P |
| 貢獻者: | 公共衛生學院醫管系;Armed Force Taichung Gen Hosp, Div Cardiol, Sect 2, Taichung, Taiwan;China Med Univ, Dept Hlth Serv Managemnet, Taichung, Taiwan;Natl Yang Ming Univ, Community Med Res Ctr, Taipei 112, Taiwan;Natl Yang Ming Univ, Inst Publ Hlth, Taipei 112, Taiwan;Shung Shan Med Univ Hosp, Div Cardiol, Taichung, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 14:01:13 (UTC+8) |
| 出版者: | INTERNATIONAL HEART JOURNAL ASSOCIATION |
| 摘要: | Flavonoids are constituents of fruits, vegetables, and plant-derived beverages, as well as components in herbal containing dietary supplements. They exhibit a remarkable spectrum of biochemical and pharmacological activities. In this study, we examined morin (3,5,7,2',4'-pentahydroxyflavone) for its effect on 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated human hepatocytes. Morin inhibited TPA-induced cellular transformation in Chang liver cells in a dose-dependent manner. Luciferase assay and electrophoretic mobility shift assay revealed that morin suppressed TPA-induced AP-1 activity, and the inhibition of AP-1 activity by morin was mediated through the inhibition of p38 kinase. Moreover, morin induced the S-phase arrest and inhibited the DNA synthesis in TPA-treated hepatocytes, suggesting that a cell cycle checkpoint was activated by morin to block DNA synthesis in S phase. In conclusion, our results suggested that morin was a potent anti-hepatocellular transformation agent that inhibited cellular transformation by suppressing the AP-1 activity and inducing the S-phase arrest in human hepatocytes. (c) 2005 Elsevier Inc. All rights reserved. |
| 關聯: | INTERNATIONAL HEART JOURNAL 46(1):57-68 |
| 顯示於類別: | [醫務管理學系暨碩士班] 期刊論文
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