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資料載入中.....
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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/28915
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| 題名: | Complete recovery time after exhaustion in high-intensity work |
| 作者: | Wu, HC;Hsu, WH;Chen, T |
| 貢獻者: | 公共衛生學院職安系;Chaoyang Univ Technol, Dept Ind Engn & Management, Taichung 41349, Taiwan;China Med Univ, Dept Occupat Safety & Hlth, Taichung 404, Taiwan;China Med Univ, Inst Environm Med, Taichung 404, Taiwan;Feng Chia Univ, Dept Ind Engn & Syst Management, Taichung 407, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 14:01:07 (UTC+8) |
| 出版者: | TAYLOR & FRANCIS LTD |
| 摘要: | This hospital-based case-control study examined whether polymorphic DNA repair genes: XRCC1 Arg399Gln, XRCC3 Thr241Met and XPD Lys751Gln, play a role in the susceptibility to colorectal cancer. We genotyped these polymorphisms for 727 newly diagnosed colorectal adenocarcinoma cases and 736 age and sex matched healthy controls in Taiwan. Although the colorectal cancer risk was not significantly associated with these genes, the risk was significantly elevated in younger subjects (<= 60 years) with the XRCC1 399Arg/Arg genotype compared to those with XRCC1 399Gln allele (OR= 1.46, 95% CI= 1.06-2.99, P = 0.02). The stratified analysis showed that XRCC3 interacted with meat consumption (P for interaction = 0.02), but was limited to the low meat consumption (OR= 2.34, 95% CI = 1.28-4.29). Our results suggest that the XRCC1 Arg399Gln polymorphism may contribute to the risk of early-onset colorectal cancer and the XRCC3 Thr241Met polymorphism may modify the risk for meat-associated colorectal cancer. (c) 2005 Elsevier Ireland Ltd. All rights reserved. |
| 關聯: | ERGONOMICS 48(6):668-679 |
| 顯示於類別: | [醫務管理學系暨碩士班] 期刊論文
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