Several new acetyl-4H,9H-naphtho[2,3-b]thiophene-4,9 ware synthesized and evaluated for in vitro cytotoxicity by NCI against seven cancer cell types. 2,7-Diacetyl naphtho[2,3-b] thiophene-4,9-dione (9) showed significant cytotoxicity against leukemia cells with log GI(50) values of-7.61 against SR cells and 7.18 against MOLT-4 cells. 3-Acetyl-naphtho[2,3-b]thiophene-4,9-dione (6) also demonstrated potent cytotoxicity in the latter cell line with log GI(50) < -8. (C) 1998 Elsevier Science Ltd. All rights reserved.
關聯:
JOURNAL OF ENVIRONMENTAL ENGINEERING-ASCE 124(11):1054-1060
