Polymorphisms of the XRCC1, XRCC3, & XPD genes, and colorectal cancer risk: a case-control study in Taiwan

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Title:	Polymorphisms of the XRCC1, XRCC3, & XPD genes, and colorectal cancer risk: a case-control study in Taiwan
Authors:	Yeh, CC;Sung, FC;Tang, RP;Chang-Chieh, CR;Hsieh, LL
Contributors:	公共衛生學院環醫所;Chang Gung Univ, Dept Publ Hlth, Tao Yuan 333, Taiwan;Natl Taiwan Univ, Coll Publ Hlth, Inst Environm Hlth, Taipei 100, Taiwan;China Med Univ, Inst Environm Hlth, Taichung 404, Taiwan;China Med Univ, Coll Publ Hlth, Dept Risk Managmenet, Taichung 404, Taiwan;Chang Gung Mem Hosp, Colorectal Sect, Linkou, Taiwan
Date:	2005
Issue Date:	2010-09-24 13:59:32 (UTC+8)
Publisher:	BIOMED CENTRAL LTD
Abstract:	Purpose: To determine the efficacy, predictability, stability and safety of laser in situ keratomileusis (LASIK) in treating patients with different degrees of myopia. Methods: We enrolled 386 eyes of 200 consecutive patients who underwent LASIK and divided them into four groups according to their degree of preoperative spherical equivalent (SE). Group 1 eyes ranged between - 1.00 and - 3.99 dioptres (D) (low myopia). Group 2 eyes ranged between - 4.00 and - 5.99D (moderate myopia). Group 3 eyes ranged between - 6.00 and - 9.99D (high myopia). Group 4 eyes were over - 9.99D (extreme myopia). Follow- up was at 1 day, 1 week and 1, 3, 6, 12 and 18 months postoperatively. Results: Our study included 386 eyes of 200 patients with SE ranging from - 3.00 to - 16.00D (mean - 7.14 +/- 2.87 D). All eyes were seen at 1 day postoperatively. A total of 360 eyes (93%) were examined at 1 week, 330 eyes (85%) at 1 month, 281 eyes (73%) at 3months, 247 eyes (64%) at 6 months, 199 eyes (52%) at 12months and 142 eyes (37%) at 18months. The postoperative data from 1 day to 12months were used because of the low follow- up rate at 18months postoperatively. Group 1 consisted of 30 eyes. The mean SE was - 3.52 +/- 0.43D preoperatively and - 0.40 +/- 0.58D at 1month, - 0.46 +/- 0.60D at 6months and - 0.42 +/- 0.50D at 12months postoperatively. Uncorrected visual acuity (UCVA) was 20/40 or better in 95% of eyes at 1 day and in 100% of eyes at 6 and 12months postoperatively. Group 2 consisted of 151 eyes. The mean SE was - 5.36 +/- 0.67D preoperatively and - 0.54 +/- 0.78D at 1month, - 0.56 +/- 0.90D at 6 months and - 0.55 +/- 0.82D at 12months postoperatively. Uncorrected visual acuity (UCVA) was 20/ 40 or better in 95% of eyes at 1 day and in 100% of eyes at 6 and 12months postoperatively. Group 3 consisted of 167 eyes. The mean SE was - 8.15 +/- 0.94D preoperatively and - 0.58 +/- 0.90D at 1month, - 0.67 +/- 1.00D at 6months and - 0.64 +/- 0.95D at 12months postoperatively. Uncorrected VA was 20/ 40 or better in 90% of eyes at 1 day and in 98% of eyes at 6 and 12months postoperatively. Group 4 consisted of 38 eyes. The mean SE was - 11.09 +/- 1.10D preoperatively and - 1.25 +/- 1.20D at 1month, - 1.13 +/- 1.30D at 6months and - 1.20 +/- 1.25D at 12months postoperatively. Uncorrected VA was 20/ 40 or better in 78% of eyes at 1 day, in 94% at 6months and in 90% at 12months postoperatively. Intraoperative complications (free cap) occurred in two eyes and postoperative complications were observed in three eyes, making the total complications rate 1.29% (5/386). Seven eyes lost one Snellen line of BCVA, five lost two lines and two lost more than two lines (total: 3.64%, 14/386). Conclusion: In conclusion, LASIK is effective, predictable and safe for correcting myopia but is more accurate for correcting myopia up to - 10.00 D. With more improvement in algorithms and ablation profile, we believe that LASIK can offer better results for higher myopia.
Relation:	BMC CANCER 5():-
Appears in Collections:	[Graduate Institute of Environmental Medicine] Journal articles

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