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http://ir.cmu.edu.tw/ir/handle/310903500/28869
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| 題名: | Effects on sister chromatid exchange frequency of polymorphisms in DNA repair gene XRCC1 in smokers |
| 作者: | Lei, YC;Hwang, SJ;Chang, CC;Kuo, HW;Luo, JC;Chang, MJW;Cheng, TJ |
| 貢獻者: | 公共衛生學院環醫所;Natl Taiwan Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, Taipei, Taiwan;China Med Coll, Inst Environm Hlth, Taichung, Taiwan;Chang Gung Univ, Coll Med, Tao Yuan, Taiwan |
| 日期: | 2002 |
| 上傳時間: | 2010-09-24 13:58:49 (UTC+8) |
| 出版者: | ELSEVIER SCIENCE BV |
| 摘要: | While the cause of Parkinson's disease (PD) remains unknown, recent evidence suggests certain environmental factors, such as well water drinking, herbicides and pesticides exposure, and neurotoxins, may trigger the chain of oxidative reactions culminating in the death of dopaminergic neurons in substantia nigra to cause parkinsonism. Most studies to date focused on PD with old age onset. However, there is a peculiar group of parkinsonian patients, the young onset Parkinson's disease (YOPD), in whom the age of onset is before 40. It is intriguing to know whether earlier exposure to the putative neurotoxin(s) may contribute to the earlier onset. We therefore conducted this case-control study in which 60 PD patients, 30 YOPD patients and the same number of age- and sex-matched young controls were included. Using logistic regression, we found well water drinking and head injury were risk factors for the development of YOPD. When YOPD patients were compared with PD, we found head injury and exercise were the significant predictors. Keeping all other variables constant, head injury was a risk factor and exercise appeared to be a protective factor. We conclude early exposure to well water drinking and head trauma may trigger and expedite the appearance of parkinsonian features, but such acceleration may be prevented through regular exercise. (C) 2002 Elsevier Science B.V. All rights reserved. |
| 關聯: | MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 519(1月2日):93-101 |
| 顯示於類別: | [環境醫學研究所(已停用)] 期刊論文
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