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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/28862
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| 題名: | Cytogenetic study of workers exposed to chromium compounds |
| 作者: | Wu, FY;Tsai, FJ;Kuo, HW;Tsai, CH;Wu, WY;Wang, RY;Lai, JS |
| 貢獻者: | 公共衛生學院環醫所;China Med Coll, Inst Environm Hlth, Taichung, Taiwan;China Med Coll Hosp, Dept Pediat, Taichung, Taiwan |
| 日期: | 2000 |
| 上傳時間: | 2010-09-24 13:58:37 (UTC+8) |
| 出版者: | ELSEVIER SCIENCE BV |
| 摘要: | Inhibitors of tubulin polymerization interacting at the colchicine binding site are potential anticancer agents. We have been involved in the synthesis of a number of colchicine site agents, such as thiocolchicinoids and allocolchicinoids, which are colchicine analogues, and 2-phenylquinolones and 2-aryl-naphthyridinones, which are the amino analogue a of cytotoxic antimitotic flavonoids. The most cytotoxic of the latter compounds strongly inhibit binding of radiolabeled colchicine to tubulin, and these agents therefore probably bind in the colchicine site of tubulin. We have applied conventional CoMFA and q(2)-GRS CoMFA to identify the essential structural requirements for increasing the ability of these compounds to form tubulin complexes. The CoMFA model for the training set of 51 compounds yielded cross-validated. R-2 (q(2)) values of 0.637 for conventional CoMFA and 0.692 for q(2)-GRS CoMFA. The predictive power of this model was confirmed by successful activity prediction for a test set of 53 compounds with known potencies as inhibitors of tubulin polymerization. The activities of 88% of the compounds were predicted with absolute value of residuals of less than 0.5. The predictive q(2) values were 0.546 for conventional CoMFA and 0.426 for q(2)-GRS CoMFA. The conventional CoMFA model with the highest predictive q(2) (0.546) was analyzed in detail in terms of underlying structure-activity relationships. |
| 關聯: | MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 464(2):289-296 |
| 顯示於類別: | [環境醫學研究所(已停用)] 期刊論文
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