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http://ir.cmu.edu.tw/ir/handle/310903500/28829
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| 題名: | Analysis of N7-(benzo[a]pyrene-6-yl) guanine in urine using two-step solid-phase extraction and isotope dilution with liquid chromatography tandem mass spectrometry |
| 作者: | Chen, YL;Wang, CJ;Wu, KY |
| 貢獻者: | 公共衛生學院風險管理系;Natl Hlth Res Inst, Div Environm Hlth & Occupat Med, Kaohsiung 807, Taiwan;China Med Univ, Dept Risk Management, Taichung 404, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 13:56:33 (UTC+8) |
| 出版者: | JOHN WILEY & SONS LTD |
| 摘要: | Genetic factors and the influence of superoxide are known to play roles in the etiology of glaucoma. We evaluated the association between primary open angle glaucoma (POAG) and two polymorphisms in the epithelial nitric oxide synthase (eNOS) gene, and one polymorphism in the myeloperoxidase (MPO) gene. We enrolled 66 patients with POAG and 100 healthy volunteers in this study. The polymorphisms in the eNOS and the polymorphism MPO -463 G-to-A in the MPO gene were resolved by polymorphism polymerase chain reaction (PCR). There were no significant differences in the distribution of the eNOS intron -4 (P=0.481), eNOS promotor -786 (P=0.555), and MPO-463 (P=0.292) gene polymorphisms between the POAG patients and the volunteers (P-values=0.481, 0.555, and 0.292, respectively). None of the alleles from either gene differed between the groups (P-values=0.483, 0.554, and 0.183, respectively). Superoxide is closely related to glaucoma, and eNOS and MPO are two important enzymes in the free radical pathway. However, polymorphisms of the eNOS intron-4, eNOS promotor -786, and MPO -463 gene polymorphisms did not reveal significant differences between POAG patients and controls in our study. The use of these agents and other superoxide-related genes for clinical applications requires further investigation. (c) 2005 Wiley-Liss, Inc. |
| 關聯: | RAPID COMMUNICATIONS IN MASS SPECTROMETRY 19(7):893-898 |
| 顯示於類別: | [健康風險管理學系] 期刊論文
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