Three-dimensional computed tomography and polysonmography findings after extended uvulopalatal flap surgery for obstructive sleep apnea

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Title:	Three-dimensional computed tomography and polysonmography findings after extended uvulopalatal flap surgery for obstructive sleep apnea
Authors:	Li, HY;Li, KK;Chen, NH;Wang, CJ;Liao, YF;Wang, PC
Contributors:	公共衛生學院公衛系;Cathay Gen Hosp, Dept Otolaryngol, Taipei, Taiwan;China Med Univ, Dept Publ Hlth, Taichung, Taiwan;Chang Gung Mem Hosp, Dept Otolaryngol, Taipei 10591, Taiwan;Chang Gung Mem Hosp, Div Pulm & Crit Care Med 1, Taipei 10591, Taiwan;Chang Gung Mem Hosp, Dept Radiol, Div 2, Taipei 10591, Taiwan;Chang Gung Mem Hosp, Sleep Ctr, Craniofacial Ctr, Dept Dent, Taipei 10591, Taiwan;Royal Infirm, Dept Sleep Med, Edinburgh, Midlothian, Scotland;Stanford Sleep Disorders Clin, Palo Alto, CA USA
Date:	2005
Issue Date:	2010-09-24 13:55:42 (UTC+8)
Publisher:	W B SAUNDERS CO
Abstract:	Background: Polymorphisms within intron 7 of the tryptophan hydroxylase (TPH1) gene were found to be associated with alcohol dependence in different ethnic groups, including the aboriginal Bunun group in Taiwan. This study aimed to identify genetic variants at the TPH1 locus and to examine their associations with alcoholism. We hypothesized that the polymorphism of TPH1 gene is functional and influences the human circadian rhythm to contribute to the pathophysiology of alcohol dependence. Methods: DNA from the Taiwanese Han and Bunun was subjected to sequence for screening genetic variation in the coding and promoter regions of the TPH1 locus. Polymorphisms among individuals with alcohol dependence and control subjects in two ethnic groups in Taiwan were investigated. Results: Three variants in the TPH1 promoter region were identified, and the markers are in complete linkage disequilibrium in both populations. Positive associations at both allelic and genotypic levels were obtained between case and control groups in the Bumm. Expression studies demonstrated that the variants indeed affected reporter gene activity in human choriocarcinoma and colon adenocarcinoma cell lines. Conclusions: Polymorphisms in the promoter region may influence the function of the TPH1 gene and further influence the proclivity of alcohol dependence in one ethnic group in Taiwan. The associations between TPH1 genotypes and alcoholism may deserve further investigation.
Relation:	AMERICAN JOURNAL OF OTOLARYNGOLOGY 26(1):7-11
Appears in Collections:	[Department of Public Health] Journal articles

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