Nasal resistance in patients with obstructive sleep apnea

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 公共衛生學院 > 公共衛生學系暨碩博班 > 期刊論文 > Item 310903500/28819

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题名:	Nasal resistance in patients with obstructive sleep apnea
作者:	Li, HY;Wang, PC;Hsu, CY;Cheng, ML;Liou, CC;Chen, NH
贡献者:	公共衛生學院公衛系;Univ Edinburgh, Royal Edinburgh Infirm, Dept Sleep Med, Edinburgh EH16 4SA, Midlothian, Scotland;Chang Gung Mem Hosp, Dept Otolaryngol, Taipei, Taiwan;Cathay Gen Hosp, Dept Otolaryngol, Taipei, Taiwan;China Med Univ, Dept Publ Hlth, Taichung, Taiwan;Kaohsiung Med Univ, Dept Clin Neurosci, Kaohsiung, Taiwan;Chang Gung Med Coll, Taipei, Taiwan;Chang Gung Mem Hosp, Sleep Ctr, Dept Pulm & Crit Care Med, Taipei 10591, Taiwan
日期:	2005
上传时间:	2010-09-24 13:55:37 (UTC+8)
出版者:	KARGER
摘要:	Hyperlipidemia may induce oxidative stress, which is important in the pathogenesis of atherosclerosis. Dioscorea rhizome (DR) is the powdered form of yams, and possesses antioxidant and hypolipidemic function. We therefore investigated the antioxidative and antiatherogenic effects of DR on hyperlipidemic rabbits. The control group was fed chow containing 0.5% cholesterol and 10% corn oil. The probucol and DR groups were fed the same diet as the control group but with the addition of 100 mg probucol/kg chow and 200 mg DR/kg chow, respectively. Total cholesterol and triacylglycerol plasma levels, RBC hemolysis T-50, lucigenin chemiluminescence, and luminol chemiluminescence increased in the control group compared with the normal group, and decreased in the probucol and DR groups compared with the control group. The activity of antioxidant enzymes superoxide dismutase and catalase was significantly higher in the probucol and DR group than in the control group. The level of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in liver DNA was lower in the probucol and DR group than in the control group. Eighty percent of the intimal surface of the thoracic aorta was covered with atherosclerotic lesions in the control group but only 40% of the surface was covered in the DR group. These results suggest that supplementation with DR reduces oxidative stress and attenuates atherosclerosis in hyperlipidemic rabbits.
關聯:	ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES 67(2):70-74
显示于类别:	[公共衛生學系暨碩博班] 期刊論文

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