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    题名: The effect of crash experience on changes in risk taking among urban and rural young people
    作者: Lin, MR;Huang, WZ;Hwang, HF;Wu, HDI;Yen, LL
    贡献者: 公共衛生學院公衛系;Taipei Med Univ, Inst Injury Prevent & Control, Taipei 110, Taiwan;Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 01701 USA;Natl Taipei Coll Nursing, Dept Nursing, Taipei 112, Taiwan;China Med Coll, Sch Publ Hlth, Taichung 404, Taiwan;Natl Taiwan Univ, Coll Publ Hlth, Inst Hlth Policy & Management, Taipei 100, Taiwan
    日期: 2004
    上传时间: 2010-09-24 13:55:34 (UTC+8)
    出版者: PERGAMON-ELSEVIER SCIENCE LTD
    摘要: Previous genetic-response studies, usually without considering environmental factors, encountered great difficulties in replication of results. Although atypical antipsychotics are becoming the mainstay for schizophrenia treatment which makes an antipsychotic "atypical" remains unclear. Risperidone (a widely used atypical antipsychotic agent) and several other atypicals have high affinities for 5-HT6 and 5-HT7 receptors. This study investigated the effects of the T --> C 267 polymorphism in the 5HT(6) receptor gene and two rare Pro279Leu and Thr92Lys substitutions in the 5HT(7) receptor gene on risperidone efficacy after rigorous control for nongenetic confounders. We found an association between the T --> C 267 polymorphism of the 5HT6 receptor gene and response to risperidone in 123 acutely ill schizophrenia inpatients after adjustment for confounders. Compared to patients with the T/C 267 genotype, those with T/T 267 showed less severe positive symptoms (p = 0.006) and general psychopathology (including anxiety, depression, and cognitive dysfunctions) (p = 0.005). The T-C 267 polymorphism had no influences on negative symptoms. The two rare polymorphisms in the 5HT(7) receptor gene were not observed in our sample. In conclusion, the 5HT(6) receptor gene variant can affect risperidone response to positive symptoms and general psychopathology (but not negative symptoms) after control for nongenetic factors. (C) 2003 Elsevier B.V. All rights reserved.
    關聯: ACCIDENT ANALYSIS AND PREVENTION 36(2):213-222
    显示于类别:[公共衛生學系暨碩博班] 期刊論文

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