Calvarial bone response to a tricalcium phosphate-genipin crosslinked gelatin composite

CMUR > College of Chinese Medicine > Graduate Institute of Chinese Medical Science > Journal articles > Item 310903500/28787

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Title:	Calvarial bone response to a tricalcium phosphate-genipin crosslinked gelatin composite
Authors:	Yao, CH;Liu, BS;Hsu, SH;Chen, YS
Contributors:	中醫學院中醫所;Chungtai Inst Hlth Sci & Technol, Dept Radiol Technol, Taichung, Taiwan;Chungtai Inst Hlth Sci & Technol, Inst Biomed Engn & Mat Sci, Taichung, Taiwan;Natl Chung Hsing Univ, Dept Chem Engn, Taichung 40227, Taiwan;China Med Univ, Inst Chinese Med Sci, Lab Biomat, Taichung, Taiwan
Date:	2005
Issue Date:	2010-09-24 13:46:34 (UTC+8)
Publisher:	ELSEVIER SCI LTD
Abstract:	Conclusion. Patients who carry the T/T homozygote of CYP17 C/T gene polymorphism may have a higher risk of developing oral cancer. Objective. Cancer of the oral cavity is the most commonly seen malignancy in Taiwan, and its rising incidence poses a formidable challenge to oncologists. The CYP17 gene encodes P450c17alpha, an enzyme involved in the metabolism of steroid hormones. Tumor necrosis factor-alpha (TNF-alpha) is one of the cytokines produced by macrophages, and its function has been postulated to play a role in cancer formation. We investigated whether polymorphisms of CYP17 and TNF-alpha genes are associated with oral cancer. Material and methods. Polymorphisms of CYP17 and TNF-alpha genes were detected by polymerase chain reaction-based restriction analysis in 137 patients with oral cancer and 102 normal controls. Results. The results for the CYP 17 gene revealed a significant difference between oral cancer patients and normal controls (p = 0.0063), but there was no significant difference for the TNF-alpha gene (p = 0.4753).
Relation:	BIOMATERIALS 26(16):3065-3074
Appears in Collections:	[Graduate Institute of Chinese Medical Science] Journal articles

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