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http://ir.cmu.edu.tw/ir/handle/310903500/28784
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| 題名: | An in vivo evaluation of a biodegradable genipin-cross-linked gelatin peripheral nerve guide conduit material |
| 作者: | Chen, YS;Chang, JY;Cheng, CY;Tsai, FJ;Yao, CH;Liu, BS |
| 貢獻者: | 中醫學院中醫所;China Med Univ, Inst Chinese Med Sci, Lab Biomat, Taichung, Taiwan;China Med Univ, Dept Med Radiol Technol, Taichung, Taiwan;Changhua Christian Hosp, Div Neurosurg, Changhua, Taiwan;Chung Tai Inst Hlth Sci & Technol, Inst Biomed Engn & Mat Sci, Taichung, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 13:46:27 (UTC+8) |
| 出版者: | ELSEVIER SCI LTD |
| 摘要: | The aim of this study was to evaluate the efficacy and safety of a Chinese herbal formula modified Mai-Men-Dong-Tang (mMMDT) for treatment of persistent, mild-to-moderate asthma. A total of 100 asthmatic patients were enrolled and assigned to three treatment groups in this double-blind, randomized, placebo-controlled clinical trial. Over a period of 4 months, patients in groups A and B received 80 and 40 mg/kg/day of mMMDT, while those in group C received a placebo. Efficacy variables included changes in forced expiratory volume in 1 s (FEV1), symptom score, serum total immunoglobulin E (IgE), and dust mite-specific IgE. Safety assessments included complete blood count, and liver and kidney function. Relative to baseline, significantly greater increases in FEV1 were demonstrated for both A and B groups in comparison with the placebo-treated analog (both p < 0.05). Further, similar improvements in symptom score were observed for both mMMDT treatment groups. The serum total IgE for group A showed a decreasing tendency after treatment but no statistical difference was noted. Furthermore, no drug-related adverse effects were reported. Blood test, and liver and kidney function were within normal range during the study, with no marked changes demonstrated over time. In conclusion, the Chinese herbal formula mMMDT provided improvements in lung function and relieved asthma symptoms in our sample of patients. Given its efficacy and safety, we consider mMMDT a credible treatment regimen for persistent, mild-to-moderate asthma. |
| 關聯: | BIOMATERIALS 26(18):3911-3918 |
| 顯示於類別: | [中國醫學研究所] 期刊論文
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