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http://ir.cmu.edu.tw/ir/handle/310903500/28778
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| 題名: | Analysis of 7-methylguanine using isotope dilution and gas chromatography/electron-capture negative chemical ionization mass spectrometry |
| 作者: | Chiang, SY;Huang, TH;Uang, SN;Wu, HDI;Wei, YC;Lin, HY;Swenberg, JA;Wu, KY |
| 貢獻者: | 中醫學院中醫所;Natl Hlth Res Inst, Div Environm Hlth & Occupat Med, Kaohsiung, Taiwan;China Med Univ, Inst Chinese Med Sci, Taichung, Taiwan;China Med Univ, Dept Pharm, Taichung, Taiwan;NIOSH, Council Labor Affairs, Div Method Dev & Anal, Taipei, Taiwan;China Med Univ, Sch Publ Hlth, Inst Environm Med, Taichung, Taiwan;Univ N Carolina, Dept Environm Sci & Engn, Chapel Hill, NC 27599 USA;China Med Univ, Dept Risk Management, Taichung, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 13:46:12 (UTC+8) |
| 出版者: | JOHN WILEY & SONS LTD |
| 摘要: | Aim: To investigate the factors affecting the outcome of fulminant hepatic failure (FHF) in children in relation to hepatitis B virus (HBV) infection. Methods: Retrospective review of a total of 94 cases (61 males and 33 females, aged from I month to 15 years) recruited from nine tertiary referral centers in Taiwan from 1985 to 1999. Results: The overall mortality rate was 75%. Patients in the mortality group were of an older age, had higher peak total bilirubin levels, a longer prothrombin time, and a lower percentage of HBV positivity (P < 0.001, P = 0.003, P = 0.0027 and P = 0.042, respectively). Mortality was 65% in the HBV positive (n = 42) and 83% in the HBV negative (n = 52) group (P = 0.05). In the HBV positive group, the prothrombin time was noted to be the single factor affecting outcome (P = 0.036). In the HBV negative group, older age and higher peak value of total serum bilirubin were suggestive of poor survival rate (P < 0.001 and P = 0.006, respectively). Multivariate analysis revealed that total bilirubin was the single factor affecting outcome in the HBV-negative group. The mortality rate of HBV positive children in three consecutive time periods without liver transplantation (1985-1989, 1990-1994, 1995-1999) decreased gradually (91, 67 and 38%, respectively, with P= 0.027). This change was not observed in HBV-negative cases. Conclusions: Hepatitis B virus positive FHF had a lower mortality rate than HBV negative FHF, with each group having different factors affecting mortality. (C) 2005 Blackwell Publishing Asia Pty Ltd. |
| 關聯: | RAPID COMMUNICATIONS IN MASS SPECTROMETRY 19(14):1915-1920 |
| 顯示於類別: | [中國醫學研究所] 期刊論文
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