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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/28769
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| 題名: | Preparation of networks of gelatin and genipin as degradable biomaterials |
| 作者: | Yao, CH;Liu, BS;Chang, CJ;Hsu, SH;Chen, YS |
| 貢獻者: | 中醫學院中醫所;Chungtai Inst Hlth Sci & Technol, Dept Radiol Technol, Taichung, Taiwan;China Med Univ, Inst Chinese Med Sci, Lab Biomat, Taichung, Taiwan;Natl Chung Hsing Univ, Dept Chem Engn, Taichung 40227, Taiwan |
| 日期: | 2004 |
| 上傳時間: | 2010-09-24 13:45:41 (UTC+8) |
| 出版者: | ELSEVIER SCIENCE SA |
| 摘要: | Direct injection of VX2 cell suspension into the liver is simple and widely used. Implantation of a fragment of VX2 tumour into the liver using a surgical technique has also been developed in the last decade. In this study, we compared these two methods in order to find a better modality for establishing VX2 liver mass. Forty rabbits, each weighing 2.8-3.2 kg, were divided into two groups, 20 rabbits in each. In Group 1, a tumour cell suspension containing 1 x 10(6) cells in a volume of 0.1 ml, was injected slowly into the liver parenchyma using a 27-gauge needle during laparotomy. In Group 2, a 1 mm 3 fragment of VX2 carcinoma was inoculated into the sub-capsule of the left anterior lobe of the liver. In Group 1, three rabbits showed no tumour growth and 10 rabbits showed evidence of leakage and tumour seeding outside of the liver. In Group 2, all but one rabbit showed tumour growth and none showed evidence of tumour seeding. The leakage rates were 50% and 0% for Group 1 and Group 2, respectively. Overall, the success inoculation rate was 35% for Group 1 and 95% for Group 2. In conclusion, to create the VX2 liver tumour model in rabbits, direct implantation of VX2 tumour fragment into the liver achieved better results than injecting cell suspension of VX2 tumour into the liver. |
| 關聯: | MATERIALS CHEMISTRY AND PHYSICS 83(2月3日):204-208 |
| 顯示於類別: | [中國醫學研究所] 期刊論文
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