Sho-saiko-to prevents liver fibrosis induced by bile duct ligation in rats

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Title:	Sho-saiko-to prevents liver fibrosis induced by bile duct ligation in rats
Authors:	Chen, MH;Chen, JC;Tsai, CC;Wang, WC;Chang, DC;Lin, CC;Hsieh, HY
Contributors:	中醫學院中醫所;China Med Univ, Res Inst Chinese Med, Taichung, Taiwan;China Med Univ, Sch Post Baccalaureate Chinese Med, Taichung, Taiwan;Show Chwan Mem Hosp, Dept Chinese Med, Changhua, Taiwan;Chiayi Christian Hosp, Dept Pathol & Med Res, Chiayi, Taiwan;Natl Chung Cheng Univ, Inst Mol Biol, Chiayi, Taiwan;Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung, Taiwan
Date:	2004
Issue Date:	2010-09-24 13:45:31 (UTC+8)
Publisher:	WORLD SCIENTIFIC PUBL CO PTE LTD
Abstract:	Background and Purpose: Taiwan Pediatric Oncology Group (TPOG)-W-91 is the first multi-institutional Wilms' tumor study for children in Taiwan. This clinical trial used a multidisciplinary approach, based on and similar to the National Wilms' Tumor Study 4. The study was conducted to evaluate the epidemiological characteristics and analyze the outcome of Wilms' tumor patients treated with this protocol. Methods: Ninety eight children with Wilms' tumor (WT) were analyzed for distributions of age, gender, associated congenital anomalies, tumor sites, histology, tumor weights, and clinical stages. Patients received individualized multimodality treatment based upon the histology of the tumor and clinicopathologic stage. The treatment included surgery, radiotherapy and 2-, 3-, and 4-agent active chemotherapeutic agents. Seventy patients were eligible for analysis of treatment outcome. The endpoints, were progression-free and overall survival (PFS, OS). Patients were divided into various subgroups according to the chemotherapy regimen used, tumor stage, age at diagnosis, gender, and tumor weight. The prognostic factors were evaluated and the survival rates of various clinical subgroups were compared using log-rank test. Results: The average annual incidence rate of WT was 2.9 per million children under 15 years of age. The M/F ratio was 1.04. The mean age at diagnosis was 3.7 years. All bilateral tumors occurred in females. Congenital anomalies were present in 17.3% of patients. Anaplastic histology was found in 6 of 98 cases (6.1%). The stage distribution was: I, 43.2%; II, 19.3%; III, 23.9%; IV, 6.8%; and V, 6.8%. The median follow-up time was 89.1 months (range, 1.8 to 128.1 months). The 5-year PFS rate was 0.7841 (SE, 0.04194; 53 of 70 patients) and the 5-year OS rate was 0.886 (SE, 0.038; 63 of 70 patients). Gender was found to be the only significant prognostic variable. Conclusions: This study evaluated the epidemiological characteristics, clinical features, multimodality therapy regimens, and treatment outcome of WT in Taiwan. Data obtained from this study may lead to further improvement in the prognosis of pediatric malignant solid tumor.
Relation:	AMERICAN JOURNAL OF CHINESE MEDICINE 32(2):195-207
Appears in Collections:	[Graduate Institute of Chinese Medical Science] Journal articles

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