Effect of Polygala tenuifolia root on behavioral disorders by lesioning nucleus basalis magnocellularis in rat

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Title:	Effect of Polygala tenuifolia root on behavioral disorders by lesioning nucleus basalis magnocellularis in rat
Authors:	Chen, YL;Hsieh, CL;Wu, PHB;Lin, JG
Contributors:	中醫學院中醫所;China Med Univ, Grad Inst Chinese Med Sci, Taichung, Taiwan;China Med Univ, Grad Inst Integrat Chinese & Western Med, Taichung, Taiwan;China Med Univ, Inst Chinese Pharmaceut Sci, Taichung, Taiwan
Date:	2004
Issue Date:	2010-09-24 13:45:12 (UTC+8)
Publisher:	ELSEVIER SCI IRELAND LTD
Abstract:	Strains of Serratia marcescens (isolated in a hospital during April and August 2000) resistant to ampicillin, chloramphenicol, trimethoprim-sulfamethoxazole, streptomycin, tetracycline, and gentamicin were characterized. Out of a total of 34 clinical isolates 6 (17.6 %) exhibited the extended spectrum beta-lactamases (ESBL) resistance; they were also resistant to cefotaxime (minimum inhibitory concentration, MIC greater than or equal to 128 mug/mL) but susceptible to imipenem (MIC less than or equal to 0.5 mug/mL). This multidrug resistance was shown to be transferred by a conjugative plasmid. Transconjugants revealed similar MIC profiles when compared to the parental strains. Isoelectric focusing revealed one major transferable beta-lactamase (pI 8.4) which was further identified as CTX-M-3 by PCR and gene sequencing. The presence of strains with this type of ESBL showed the evolution of bla genes and their dissemination among at least three species of the family Enterobacteriaceae isolated within a single hospital. The predominance of CTX-M type enzymes found in this area of Taiwan appeared to be similar to that described in Poland.
Relation:	JOURNAL OF ETHNOPHARMACOLOGY 95(1):47-55
Appears in Collections:	[Graduate Institute of Chinese Medical Science] Journal articles

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