Activation of activator protein 1 and extracellular signal-regulated kinases in human hepatocellular transformation

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 中醫學院 > 中國醫學研究所 > 期刊論文 > Item 310903500/28754

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题名:	Activation of activator protein 1 and extracellular signal-regulated kinases in human hepatocellular transformation
作者:	Hsiang, CY;Wu, SL;Ho, TY
贡献者:	中醫學院中醫所;China Med Univ, Inst Chinese Med Sci, Taichung 404, Taiwan;China Med Univ, Dept Microbiol, Taichung 404, Taiwan;China Med Univ, Dept Biochem, Taichung 404, Taiwan
日期:	2004
上传时间:	2010-09-24 13:45:06 (UTC+8)
出版者:	KARGER
摘要:	Objective Recent research suggests that Tourette's syndrome (TS) may result from a defect in the dopamine system. The dopamine 1 receptor (DRD1) gene is a candidate gene in the study of the etiology of neuropsychiatric diseases that may involve dopaminergic abnormalities. We sought to test the hypothesis that the DRD1 gene might play a role in TS. Methods By performing an association study, we collected an independent sample of patients from the midland region of Taiwan and investigated whether DRD1 gene polymorphisms can be used as markers of susceptibility to TS. A total of 148 children with TS and 83 normal control subjects were included in the study. A polymerase chain reaction was used to identify the A/G polymorphism of the DRD1 gene. Genotypes and allelic frequencies for the DRD1 gene polymorphisms in both groups were compared. Results The results showed that genotypes and allelic frequencies for the DRD1 gene polymorphisms in both groups were not significantly different. Conclusion These data suggest that DRD1 gene may not be a useful marker for prediction of the susceptibility of TS. (C) 2004 Lippincott Williams Wilkins.
關聯:	TUMOR BIOLOGY 25(5月6日):313-320
显示于类别:	[中國醫學研究所] 期刊論文

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