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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/28746
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| 題名: | In vitro study of the effect of doxorubicin released from EVAL membrane on vesical cancer cells |
| 作者: | Yao, CH;Chuang, WY;Chen, YS;Young, TH |
| 貢獻者: | 中醫學院中醫所;Natl Taiwan Univ, Coll Engn, Inst Mat Sci & Engn, Taipei, Taiwan;China Med Coll, Inst Chinese Med Sci, Taichung, Taiwan;Natl Taiwan Univ, Coll Med, Inst Biomed Engn, Taipei, Taiwan;Natl Taiwan Univ, Coll Engn, Taipei, Taiwan;Chungtai Inst Hlth Sci & Technol, Dept Radiol Technol, Taichung, Taiwan |
| 日期: | 2002 |
| 上傳時間: | 2010-09-24 13:44:48 (UTC+8) |
| 出版者: | ELSEVIER SCIENCE SA |
| 摘要: | Melanin was extracted from tea leaves (Thea sinensis Linn.) for the first time. Characterization of melanin proved similarity of the original compound to standard melanin, The Langmuir adsorption isotherms for gadolinium (Gd) binding were obtained using melanin. Melanin -Gd preparation demonstrated low acute toxicity. LD50, for this preparation was in a range of 1250-1500 mg/kg in mice. Magnetic Resonance Imaging (MRI) properties of melanin itself and melanin-Gd. complexes have been estimated. Gd free melanin fractions possess slighter relaxivity compared with its complexes. The relaxivity of lower molecular weight fraction was two times higher than relaxivity of Gd(DTPA) standard, Postcontrast images demonstrate that oral administration or melanin complexes in concentration 0. 1 mM provides essential enhancement to longitudinal relaxation times (T-1)-weighted spin echo image. The required contrast and delineation of the stomach wall demonstrated uniform enhancement of MRI with proposed melanin complex. (C) 2002 Elsevier Science Ireland Ltd, All rights reserved. |
| 關聯: | MATERIALS CHEMISTRY AND PHYSICS 73(1):1-5 |
| 顯示於類別: | [中國醫學研究所] 期刊論文
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