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http://ir.cmu.edu.tw/ir/handle/310903500/28734
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| 題名: | Effects of Huangqi Jianzhong Tang on hematological and biochemical parameters in judo athletes |
| 作者: | Su, YC;Lin, CJ;Chen, KT;Lee, SN;Lin, JS;Tsai, CC;Chou, Y;Lin, JG |
| 貢獻者: | 中醫學院中醫所;China Med Coll, Inst Chinese Med Sci, Taichung, Taiwan;MingHsin Inst Technol, Dept Gen Educ, Hsinchu, Taiwan;Feng Chia Univ, Inst Stat & Actuarian Sci, Taichung 40724, Taiwan;Chinese Culture Univ, Dept Phys Educ, Taipei, Taiwan |
| 日期: | 2001 |
| 上傳時間: | 2010-09-24 13:44:25 (UTC+8) |
| 出版者: | ACTA PHARMACOLOGICA SINICA |
| 摘要: | AIM: To study the prophylactic effects of four Chinese traditional prescriptions against experimental liver injury. METHODS: Liver toxins, alpha -naphthylisothiocyanate (ANIT), and carbon tetrachloride (CCl4) were used to induce acute liver injury. Simo Yin (SMY), Guizhi Fuling Wan (GFW), Xieqing Wan (XQW), and Sini San (SNS) were fed (500 mg/kg, in saline, po) to the rats before toxin administration. All the animals were killed 48 h after toxin insulted. Serum index of liver function and hepatic lipid peroxidation ( LPO) were estimated. Histopathological observation was conducted simultaneously. RESULTS: The rats treated with ANIT exhibited elevations of serum total bilirubin (TBI), alkaline phosphatase ( ALP), glutamate-oxalate-transaminase ( GOT), glutamate-pyruvate-transaminase (GPT), as well as cholestasis and parenchyma necrosis. In rats, challenged with ANIT, receiving the pretreatment of prescriptions of SMY, XQW, and SNS, the biochemical and morphological parameters of liver injury were significantly reduced. The increased LPO level in liver tissue, associated with the provoked serum GOT and GPT levels were the salient features observed in CCl4-insulting rats. Pre-treatment of four prescriptions showed a remarkable protective effect, and also was effective in counteracting the free radical toxicity by bringing about a significant decrease in peroxidative level. CONCLUSION: These recipes ameliorate liver damage induced by both ANIT and CCl4 despite the differences in their mechanisms of injury. Therefore they may be able to exert hepatoprotective effects through more than, one mechanism of action because they contained a mixture of anti-hepatotoxic ingredients with mutual reinforcement and assistance. |
| 關聯: | ACTA PHARMACOLOGICA SINICA 22(12):1154-1158 |
| 顯示於類別: | [中國醫學研究所] 期刊論文
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