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| 題名: | Crucial role of extracellular signal-regulated kinase pathway in reactive oxygen species-mediated endothelin-1 gene expression induced by endothelin-1 in rat cardiac fibroblasts |
| 作者: | Cheng, CM;Hong, HJ;Liu, JC;Shih, NL;Juan, SH;Loh, SH;Chan, P;Chen, JJ;Cheng, TH |
| 貢獻者: | 中醫學院中醫系;Taipei Med Univ, Wan Fang Hosp, Dept Med, Taipei, Taiwan;Changhua Christian Hosp, Dept Obstet & Gynecol, Changhua, Taiwan;China Med Coll, Sch Chinese Med, Taichung, Taiwan;Acad Sinica, Inst Biomed Sci, Taipei, Taiwan;Natl Def Med Ctr, Dept Pharmacol, Taipei, Taiwan |
| 日期: | 2003 |
| 上傳時間: | 2010-09-24 13:41:45 (UTC+8) |
| 出版者: | AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS |
| 摘要: | Objectives: (1) To assess whether urinary N,N-dimethylformamide (U-DMF) is suitable as a biomarker when co-exposure to methyl ethyl ketone (MEK) exists, and to evaluate whether it is suitable as an exposure biomarker of DMF. (2) To examine whether the co-exposure to MEK affects the characteristics of U-NMF and U-DMF. (3) To investigate if the difference in creatinine-adjusted and non-adjusted measurements of urinary biomarkers of DMF exposure is substantial. Methods: Personal exposure monitoring of N,N-dimethylformamide (DMF) and MEK on I I synthetic-leather workers was performed for 5 consecutive days. Daily post-shift urine for each individual was collected and was analyzed for urinary N-methylformamide (U-NMF) and U-DMF levels on both non-adjusted and creatinine-adjusted bases. Results: Both U-NMF and U-DMF showed significant associations with airborne DMF. Positive and significant associations between U-NMF and U-DMF on either a non-adjusted basis or a creatinine-adjusted basis were found. Satisfactory linear associations (P<0.01) between all kinds of urinary biomarkers and DMF exposure were found. The co-exposure to MEK exerted more effect on the relationship of airborne DMF to U-DMF than to U-NMF. Conclusions: U-DMF is detectable when occupational DMF exposure is near or below the occupational exposure limit of 10 ppm. In view of the performance of sensitivity, specificity, and positive predictive value, U-NMF, in general, is superior to U-DMF. However, on a par with other findings in this and previous studies, U-DMF might be considered as a complimentary biomarker of exposure to DMF in addition to U-NMF. No distinction between creatinine-adjustment or non-adjustment for urine specimens was found in the biological monitoring of DMF exposure. Further exploration of the influence of co-exposure to MEK at higher exposure is warranted. |
| 關聯: | MOLECULAR PHARMACOLOGY 63(5):1002-1011 |
| 顯示於類別: | [中醫學系暨碩博班] 期刊論文
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