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http://ir.cmu.edu.tw/ir/handle/310903500/28698
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| 題名: | Effects of "Chinese yam" on hepato-nephrotoxicity of acetaminophen in rats |
| 作者: | Lee, SC;Tsai, CC;Chen, JC;Lin, JG;Lin, CC;Hu, ML;Lu, S |
| 貢獻者: | 中醫學院中醫系;Natl Chung Hsing Univ, Inst Food Sci, Taichung 40227, Taiwan;China Med Coll, Sch Chinese Med, Taichung 404, Taiwan;China Med Coll, Sch Post Baccalaureate Chinese Med, Taichung 404, Taiwan;Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan |
| 日期: | 2002 |
| 上傳時間: | 2010-09-24 13:41:39 (UTC+8) |
| 出版者: | ACTA PHARMACOLOGICA SINICA |
| 摘要: | Endometriosis is defined as endometrial tissue outside of the uterine cavity. The pathogenesis of this common disease remains poorly understood. However, the implantation and invasion of the viable cells from retrograde menstruation into the peritoneum is a widely accepted theory. To date, the mechanisms by which cell adhesion molecules mediate the development of human endometriosis remain unclear. Cadherins are a family of cell adhesion molecules that mediate cell-cell adhesion in a homophilic manner. In this study, the cadherins present in the peritoneum and endometriotic lesions were identified by RT-PCR using degenerate primers. In addition, differences in the levels of the cadherin mRNA transcripts present in eutopic endometrium and endometriotic lesions of the same patients were then compared by semiquantitative RT-PCR. Multiple cadherins were detected in the peritoneum and endometriotic lesions. Of these, P-cadherin appears to be the predominant cadherin subtype present in the peritoneum. Similarly, P-cadherin mRNA levels in endometriotic lesions were significantly greater than those observed in the corresponding eutopic endometrium. The expression of P-cadherin in both the human peritoneum and endometriotic lesions suggests that this cell adhesion molecule may play a central role in the development of endometriosis by mediating endometrial-peritoneal cell interactions in a homophilic manner. |
| 關聯: | ACTA PHARMACOLOGICA SINICA 23(6):503-508 |
| 顯示於類別: | [中醫學系暨碩博班] 期刊論文
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