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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/28693
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| 題名: | Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis |
| 作者: | Huang, RL;Chen, CC;Huang, HL;Chang, CG;Chen, CF;Chang, CM;Hsieh, MT |
| 貢獻者: | 中醫學院中醫系;Natl Res Inst Chinese Med, Dept Pharmacol, Taipei 11221, Taiwan;Natl Yang Ming Univ, Inst Microbiol & Immunol, Taipei, Taiwan;China Med Coll, Dept Chinese Med, Taichung, Taiwan |
| 日期: | 2000 |
| 上傳時間: | 2010-09-24 13:41:28 (UTC+8) |
| 出版者: | GEORG THIEME VERLAG KG |
| 摘要: | The hepatoprotective effects of Tao-shang-tsao, hei is laevigatn SCH.-BIP. var, oldhami KITAM., were studied on cholestatic hepatitis induced by alpha -naphthylisothiocyanate (ANIT, 100 mg/10 ml/kg, in olive oil, i.p.) and acute hepatitis induced by carbon tetrachloride (20% CCl4/olive oil, 1.5 ml/kg, i.p.) in rats by post-treatment with the crude methanolic extracts of I. laevigata (0.3, 1.0, and 2.0 g/kg) orally in the therapeutic model. Hepatoprotective activity was monitored by estimating the serum transaminases concentrations and histopathological changes in the livers of experimental rats. It was found that the I. laevigata extract significantly decreased the acute elevation of serum transaminases by biochemical examination. According to pathohistological studies in the liver of experimental rats, the crude I. laevigata extract ameliorates the central necrosis, fatty change or proliferation of bile duct epithelium focal necrosis caused by ANIT or CCl4-induced hepatitis rats. |
| 關聯: | PLANTA MEDICA 66(8):694-698 |
| 顯示於類別: | [中醫學系暨碩博班] 期刊論文
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