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| 題名: | The interaction of H-pylori infection and NSAIDs in cyclooxygenase-2 mRNA expression in gastric antral, corpus mucosa, and gastric ulcer |
| 作者: | Wu, CY;Wu, MS;Chen, CJ;Li, MC;Lin, JT;Chen, GH |
| 貢獻者: | 中國醫藥大學;Natl Taiwan Univ, Grad Inst Clin Med, Taipei, Taiwan;Natl Taiwan Univ, Coll Med, Dept Internal Med, Taipei, Taiwan;Natl Taiwan Univ, Coll Publ Hlth, Taipei, Taiwan;Taichung Vet Gen Hosp, Div Gastroenterol, Taichung, Taiwan;Taichung Vet Gen Hosp, Dept Pathol, Taichung, Taiwan;China Med Coll, Taichung, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 13:40:22 (UTC+8) |
| 出版者: | LIPPINCOTT WILLIAMS & WILKINS |
| 摘要: | As part of a continuing search for potential anticancer drug candidates in the 2-phenyl-4-quinolone series, 3',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives and their salts were synthesized and evaluated. Preliminary screening showed that carboxylic acid analogs containing a m-fluoro substituted 2-phenyl group displayed the highest in vitro anticancer activity. Activity decreased significantly if a chlorine or methoxy group replaced the fluorine atom. 3'-Fluoro-6-methoxy-2-phenyl-4-quinolone-3-carboxylic acid (68) had the highest in vitro cytotoxic activity among all tested carboxylic acid derivatives and their salts. The mechanism of action may be similar, but not identical, to that of tubulin binding drugs, such as navelbine and taxol. Compound 68 merits further investigation as a novel hydrophilic antimitotic agent. (C) 2004 Elsevier Ltd. All rights reserved. |
| 關聯: | JOURNAL OF CLINICAL GASTROENTEROLOGY 39(1):50-55 |
| 顯示於類別: | [中醫學系暨碩博班] 期刊論文
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