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http://ir.cmu.edu.tw/ir/handle/310903500/28661
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| 題名: | Effect of a potent cyclooxygenase inhibitor, 5-ethyl-4-methoxy-2-phenylquinoline (KTC-5), on human platelets |
| 作者: | Liao, CH;Liao, CH;Chang, YL;Guh, JH;Kuo, SC;Huang, LJ;Teng, CM |
| 貢獻者: | 中國醫藥大學;Natl Taiwan Univ, Inst Pharmaceut, Coll Med, Taipei 10764, Taiwan;Chang Gung Univ, Coll Med, Grad Inst Nat Prod, Tao Yuan, Taiwan;China Med Coll, Taichung, Taiwan |
| 日期: | 2002 |
| 上傳時間: | 2010-09-24 13:39:31 (UTC+8) |
| 出版者: | ROYAL PHARMACEUTICAL SOC GREAT BRITAIN |
| 摘要: | Purpose: At present, bone metastases are usually assessed using conventional technetium-99m methylene diphosphonate whole-body bone scan, which has a high sensitivity but a poor specificity. However, positron emission tomography with F-18-2-deoxyglucose (FDG-PET) can offer superior spatial resolution and improved specificity. We attempted to evaluate the usefulness of FDG-PET for detecting bone metastases in breast cancer and to compare FDG-PET results with bone scan findings. Patients: The study group comprised 48 patients with biopsy-proven breast cancer and suspected of having bone metastases who underwent bone scan and FDG-PET to detect the bone metastases. The final diagnosis of bone metastases was established by operative, histopathological findings or during a clinical follow-up longer than I year by additional radiographs or following FDG-PET/bone scan findings showing progressive widespread bone lesions. Results: A total of 127 bone lesions including 105 metastatic and 22 benign bone lesions found by either FDG-PET or bone scan were evaluated. Using FDG-PET, 100 metastatic and 20 benign bone lesions were accurately diagnosed, and using bone scan 98 metastatic and 2 benign bone lesions were accurately diagnosed. The diagnostic sensitivity and accuracy of FDG-PET were 95.2% and 94.5%, and of bone scan were 93.3% and 78.7%, respectively. Conclusions: Our findings suggest that FDG-PET shows a similar sensitivity and a better accuracy than bone scan for detecting bone metastases in patients with breast cancer. |
| 關聯: | JOURNAL OF PHARMACY AND PHARMACOLOGY 54(7):967-973 |
| 顯示於類別: | [中國醫藥大學] 期刊論文
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