Marked lung uptake of Tc-99m HMPAO in a polysubstance-abusing marijuana and tobacco smoker

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Title:	Marked lung uptake of Tc-99m HMPAO in a polysubstance-abusing marijuana and tobacco smoker
Authors:	Shih, WJ;Carmona, JJ;Coupal, JJ;Lee, JK
Contributors:	中國醫藥大學;VET ADM MED CTR,PSYCHIAT SERV,LEXINGTON,KY 40511;UNIV KENTUCKY,MED CTR,LEXINGTON,KY;CHINA MED COLL,TAICHUNG,TAIWAN
Date:	1996
Issue Date:	2010-09-24 13:38:52 (UTC+8)
Publisher:	LIPPINCOTT-RAVEN PUBL
Abstract:	Objective. To investigate photofrin (Pf) II and laser irradiation on mice bearing subcutaneous tumors. Method. Ehrlish ascites tumor cells (1 x 10(7)) were implanted subcutaneously into the breast area of ICR mice. The tumors, when grew up to 0.55 +/- 0.15cm(3), was administered of laser irradiation (514.5nm, 112.5mW/cm(2) for 11.12 min with total energy 75J/cm(2)) after intraperitoneal injection of Pf II (5, 7.5, 10 and 15mg/kg body weight) once a day for three successive days. Results. The mortality rate (MR(120)) in the tumor control was 93.7% and the mean survival time (MST(120)) was 46.6 days. The best therapeutic effect (50% mortality rate, 53.8% tumor control rate and mean survival time 86 days) was observed in the group treated with 7.5mg of Pf II per kg of body weight and total irradiation energy of 75J/cm(2) (112.5mW/cm(2) for 11.12 min) with 514.5nm argon ion laser light. Conclusions. The effect on the survival rate of tumor cells and synthetic rates of DNA, RNA and protein were obviously inhibited, as the dose of pf II and laser irradiation increased.
Relation:	CLINICAL NUCLEAR MEDICINE 21(2):156-156
Appears in Collections:	[China Medical University] Journal articles

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