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| 題名: | TRANSESOPHAGEAL ECHOCARDIOGRAPHY IN ADULTS WITH A CONTINUOUS PRECORDIAL MURMUR |
| 作者: | CHEN, YT;LEE, YS;KAN, MN;CHEN, JS;HU, WS;LIN, WW;WANG, KY;LIN, CJ;CHIANG, BN |
| 貢獻者: | 中國醫藥大學;CHUNG SHAN MED & DENT COLL,TAICHUNG 40705,TAIWAN;CHINA MED COLL,TAICHUNG 40705,TAIWAN |
| 日期: | 1992 |
| 上傳時間: | 2010-09-24 13:38:44 (UTC+8) |
| 出版者: | ELSEVIER SCI IRELAND LTD |
| 摘要: | HA-29, 2-[(3-methoxyphenyl)methyl]-pyrano[2,3-c]pyrazol-6(H-1)-one, was investigated for its inhibitory mechanism of action in washed rabbit platelets. This compound inhibited the aggregation and ATP release of rabbit platelets induced by arachidonic acid and collagen in a concentration-dependent manner, without affecting those induced by ADP, PAF and thrombin. Prolongation of the incubation time of HA-29 with platelets did not cause further inhibition and the aggregability of the agent-treated platelets could be restored after washing of platelets. The concentration-response curve of U-46619-induced platelet aggregation was shifted to the right by HA-29 in a concentration-dependent manner, but the maximal aggregation was suppressed by HA-29. The pA2 and pA10 values of HA-29 on U-46619-induced platelet aggregation were 4.26 and 3.58, respectively, with a slope value of -1.4. The U-46619-induced aggregation was markedly disaggregated by HA-29 even it was added 5 min after U-46619. HA-29 inhibited the secondary aggregation and ATP release, but not the primary aggregation of human platelet-rich plasma induced by ADP and epinephrine. Thromboxane B2 formation caused by arachidonic acid, collagen and thrombin was markedly suppressed by HA-29. HA-29 also inhibited the formation of prostaglandin D2 caused by arachidonic acid. HA-29 inhibited almost completely the formation of inositol monophosphate caused by U-46619, but not that by collagen or thrombin. HA-29 did not affect U-46619-induced contraction of rat aorta. It is concluded that the antiplatelet effect of HA-29 is due to the inhibition of thromboxane A2 formation and blockade of thromboxane A2/prostaglandin endoperoxide receptor. |
| 關聯: | INTERNATIONAL JOURNAL OF CARDIOLOGY 36(1):61-68 |
| 顯示於類別: | [中國醫藥大學] 期刊論文
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