Polymorphisms of TAP1 transporter genes in Chinese patients with systemic lupus erythematosus in Taiwan.

CMUR > College of Chinese Medicine > School of Chinese Medicine > Journal articles > Item 310903500/2848

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/2848

Title:	Polymorphisms of TAP1 transporter genes in Chinese patients with systemic lupus erythematosus in Taiwan.
Authors:	黃春明(Chung-Ming Huang);杭良文(Liang-Wen Hang);(Chi-Lan Chen);鄔哲源;蔡輔仁(Fuu-Jen Tsai)*
Contributors:	中醫學院中醫學系學士班中醫內科學科;中國附醫內科部風濕免疫科
Keywords:	Polymorphism;Single nucleotide polymorphisms;Systemic lupus erythematosus;Transporter and antigen processor
Date:	2004
Issue Date:	2009-08-20 17:57:07 (UTC+8)
Abstract:	The aim of this study was to determine how polymorphisms of transporters associated with transporter and antigen processing 1 (TAP1) alleles contributed to the pathogenesis of systemic lupus erythematosus (SLE) in Taiwan. We collected 88 patients with SLE and 104 healthy people for the control group. The polymorphisms were detected as a result of polymerase chain reaction (PCR)-based restriction analysis. Associations between SLE and TAP1 polymorphisms were evaluated. The results revealed no significant differences between the healthy individuals and SLE patients with TAP1-1 (Dpn II) and TAP1-2 (Acc I) polymorphisms (P=0.10 and 0.36, respectively). However, the G alleles of TAP1-1 and TAP1-2 were significantly more common than the A alleles in serositis of SLE patients (2=11.16 and P=0.004, 2=8.10 and P=0.02, respectively).
Relation:	RHEUMATOLOGY INTERNATIONAL 24(3):130~132
Appears in Collections:	[School of Chinese Medicine] Journal articles

Files in This Item:

File	Size	Format
	0Kb	Unknown	424	View/Open