Effects of Protocatechuic Acid on Trans Fat Induced Hepatic Steatosis in Mice

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Title:	Effects of Protocatechuic Acid on Trans Fat Induced Hepatic Steatosis in Mice
Authors:	(WEN-HU LIU);(CHUN-CHE LIN);(ZHI-HONG WANG);(MEI-CHIN MONG);殷梅津(YIN, MEI-CHIN)*
Contributors:	健康照護學院營養學系
Keywords:	Trans fatty acid;protocatechuic acid;hepatic steatosis;stearoyl-CoA desaturase-1
Date:	2010-09
Issue Date:	2010-09-23 19:56:58 (UTC+8)
Abstract:	The effects of protocatechuic acid (PCA) on hepatic activity and/or mRNA expression of lipogenic enzymes and sterol regulatory element-binding proteins (SREBPs) in mice fed a trans fatty acid (TFA)-rich diet were examined. PCA at 1, 2, or 4% was provided for 10 weeks. Results showed that TFA diet significantly enhanced hepatic activity and mRNA expression of fatty acid synthase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, stearoyl-CoA desaturase-1, and SREBP-1c (P < 0.05); however, the intake of PCA significantly diminished the activity and mRNA expression of these lipogenic factors and decreased hepatic lipid accumulation (P < 0.05). TFA diet significantly increased hepatic levels of TFA and pro-inflammatory cytokines (P < 0.05). However, PCA intake significantly lowered hepatic content of 18:1 trans and 18:2 trans, as well as reduced the level of test cytokines (P < 0.05). These results indicate that PCA is a potent agent for attenuating TFA-induced hepatic steatosis.
Relation:	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 58():10247-10252
Appears in Collections:	[Graduate Institute of Nutrition ] Journal articles

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