Exercise pretraining attenuates endotoxin-induced hemodynamic alteration in type I diabetic rats

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 健康照護學院 > 物理治療學系暨復健科學碩士班 > 期刊論文 > Item 310903500/28453

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.cmu.edu.tw/ir/handle/310903500/28453

题名:	Exercise pretraining attenuates endotoxin-induced hemodynamic alteration in type I diabetic rats
作者:	陳郁文(Yu-Wen Chen);(Hung,C.H.);(Shao,D.Z.);(Chang,C.N.);(Tsai,Y.Y.);(Cheng,J.T.)*
贡献者:	健康照護學院物理治療學系
关键词:	endotoxemia;exercise;hemodynamic;HSP72;tumor necrosis factor α;diabète;endotoxémie;exercice physique;facteur de nécrose tumorale α;hémodynamique;HSP72
日期:	2008-10
上传时间:	2010-09-23 19:55:52 (UTC+8)
摘要:	Higher expression of heat shock protein 72 (HSP72) reduces the mortality rate and organ damage in septic shock and prevents cardiac mitochondrial dysfunction due to lipopolysaccharide (LPS). Our hypothesis is that exercise preconditioning may increase the expression of HSP72 in heart and the nucleus tractus solitarii (NTS) of the brain to alleviate the cardiovascular dysfunction in type I diabetic rats receiving endotoxin. Wistar rats were randomly assigned to the following groups: sedentary normal, sedentary type I diabetic rats, and type I diabetic rats with exercise training. The trained rats ran on a treadmill 5 d.week-1, 30-60 min.d-1, at an intensity of 1.0 mile.h-1 (1 mile = 1.6 km) over a 3 week period. Twenty-four hours after the last training session, we compared the temporal profiles of mean arterial pressure, heart rate, cardiac output, stroke volume, and serum tumor necrosis factor alpha level in rats receiving an injection of LPS. In addition, HSP72 expression in heart and NTS from each group was determined. We found that HSP72 expression in the heart and NTS was significantly increased in diabetic rats with exercise training. After administration of LPS, the survival time was significantly longer in diabetic rats with exercise training. Additionaly, serum tumor necrosis factor alpha levels decreased as compared with those rats not receiving exercise training. Exercise training also diminished cardiovascular dysfunction in diabetic rats during endotoxemia. These data suggest that exercise may increase the expression of HSP72 in the heart and NTS to protect against the high mortality rate and attenuate cardiovascular dysfunction in diabetic rats during endotoxemia.
關聯:	Applied Physiology Nutrition and Metabolism-Physiologie appliquee nutrition 33(5):976-983
显示于类别:	[物理治療學系暨復健科學碩士班] 期刊論文

文件中的档案:

没有与此文件相关的档案.

在CMUR中所有的数据项都受到原著作权保护.

TAIR相关文章

数据加载中.....