Chorioallantoic membrane assays have been based on diffusion control—Problems arising with a diversity of

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 健康照護學院 > 物理治療學系暨復健科學碩士班 > 期刊論文 > Item 310903500/28443

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题名:	Chorioallantoic membrane assays have been based on diffusion control—Problems arising with a diversity of
作者:	彭瓊琦(Chiung-Chi Peng);(Chiu-Lan Hsieh);(Li-Yun Lin);(Yu-Ting Cheng);(Kuan-Chou Chend);(Robert Y. Peng)
贡献者:	健康照護學院物理治療學系
关键词:	Diffusion control;Kinetic control;Chorioallantoic membrane (CAM) assay
日期:	2009-01
上传时间:	2010-09-23 19:55:34 (UTC+8)
摘要:	The chorioallantoic membrane (CAM) assays have been intensively used to determine angiogenesis and anti-angiogenesis of medicines. In view of bioactivity, this technique should be performed with kinetic control regime in chicken embryos. Whether the dosages ever used had satisfied this requirement, we explored by mathematical analysis. A diffusion-in-egg model was established to describe several medicinal diffusions in egg white that involved the instantaneous transient kinetic behavior, the diffusion of medicines in capping volume (the volume from the air sac to the interface of egg yolk). By reviewing the diffusion of various compounds including the cited and the experimentals in this work, we conclude that all the CAM assays ever cited were performed under diffusion control regime rather than kinetic control, which may bring forth deviations caused by a diversity of constitutes in egg white through various medicine-protein interactions.
關聯:	COLLOIDS AND SURFACES B-BIOINTERFACES 68(1):74-78
显示于类别:	[物理治療學系暨復健科學碩士班] 期刊論文

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