Action Mechanism and Signal Pathways of Psidium guajava L. Aqueous Extract in Killing Prostate Cancer LNCaP Cells

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 健康照護學院 > 物理治療學系暨復健科學碩士班 > 期刊論文 > Item 310903500/28428

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题名:	Action Mechanism and Signal Pathways of Psidium guajava L. Aqueous Extract in Killing Prostate Cancer LNCaP Cells
作者:	(Chen KC);彭瓊琦(Chiung-Chi Peng);(Chiu WT);(Cheng YT);(Huang GT);(Hsieh CL);(Peng RY)*
贡献者:	健康照護學院物理治療學系
日期:	2010-02
上传时间:	2010-09-23 19:55:07 (UTC+8)
摘要:	Aqueous extract of Psidium guajava L. budding leaves (PE) has been shown to possess anti-prostate cancer activity in a cell line model. We examined whether its bioactivity could be conserved either in the presence or the absence of synthetic androgen R1881. In both cases, PE was shown to inhibit LNCaP cell proliferation and down-regulate expressions of androgen receptor (AR) and prostate specific antigen (PSA). The cytotoxicity of PE was shown by enhanced LDH release in LNCaP cells. The flow cytometry analysis revealed cell cycle arrests at G0/G1 phase with huge amount of apoptotic LNCaP cells after treatment with PE for 48 h in a dose-responsive manner, which was also confirmed by TUNEL assay. From the results of decreased Bcl-2/Bax ratio, inactivation of phosphor-Akt, activation of phosphor-p38, phospho-Erk1/phospho-Erk2, the molecular action mechanism of PE to induce apoptosis in LNCaP cells was elucidated. Compatible with the in vitro study findings, treatment with PE (1.5 mg/mouse/day) significantly diminished both the PSA serum levels and tumor size in a xenograft mouse tumor model. Conclusively, PE is a promising anti-androgen-sensative prostate cancer agent.
關聯:	NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL 62(2):260-270
显示于类别:	[物理治療學系暨復健科學碩士班] 期刊論文

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