Diphenidol inhibited sodium currents and produced spinal anesthesia

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Title:	Diphenidol inhibited sodium currents and produced spinal anesthesia
Authors:	梁育民;吳柏蒼(Bor-Tsang Wu);(Yu-Chung Chen);(Ching-Hsia Hung);陳郁文(Yu-Wen Chen)
Contributors:	健康照護學院物理治療學系
Keywords:	Diphenidol;Sodium currents;Spinal anesthesia
Date:	2010-06
Issue Date:	2010-09-23 19:54:52 (UTC+8)
Abstract:	The aim of this study was to evaluate the effect of diphenidol on blocking Na+ currents and spinal anesthesia. We used the patch-clamp method to examine if diphenidol blocked Na+ currents. Lidocaine, a common used local anesthesia, was used as control. We also evaluated the potencies and durations of diphenidol and lidocaine on spinal blockades of motor function, proprioception, and nociception in rats. Lidocaine exhibited a concentration- and state-dependent effect on tonic blockade of voltage-gated Na+ currents in mouse neuroblastoma N2A cells (IC50 of 8.1 and 138.9 μM at holding potentials of −70 and −100 mV, respectively). Diphenidol was more potent (IC50 of 0.77 and 62.6 μM at holding potentials of −70 and −100 mV, respectively). However, unlike lidocaine, block of Na+ currents by diphenidol lacked use-dependence. We also found that diphenidol acted like lidocaine and produced dose-related spinal blockades of motor function, proprioception and nociception. Although diphenidol had similar potencies of spinal anesthesia compared with lidocaine it produced a much longer duration of spinal blockades than lidocaine. Our results demonstrated that intrathecal diphenidol produced a long duration and similar potency on spinal anesthesia compared with lidocaine in rats. The anesthetic effect of diphenidol could be in part due to its blockade of Na+ currents.
Relation:	NEUROPHARMACOLOGY 58():1147-1152
Appears in Collections:	[Department of Physical Therapy, Graduate Institute of Rehabilitation Science] Journal articles

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