中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/28417
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    Title: Insulin Secretagogue Bioactivity of Finger Citron Fruit(Citrus medica L. var. Sarcodactylis Hort, Rutaceae)
    Authors: (CHIUNG-HUEI PENG);(YAW-BEE KER);(CHING-FENG WENG);彭瓊琦(Chiung-Chi Peng);(CHIEN-NING HUANG)*;(LI-YUN LIN);(ROBERT Y. PENG)
    Contributors: 健康照護學院物理治療學系
    Keywords: Insulin secretagogue;antiobese;type 2 diabetes mellitus;finger citron fruits
    Date: 2009
    Issue Date: 2010-09-23 19:54:48 (UTC+8)
    Abstract: Finger citron [Citrus medica L. var. Sarcodactylis Hort, Rutaceae] (FC) fruits, widely cultivated in Japan, the southern provinces of China and Taiwan, are commonly used as functional vegetables and preserved as sweetmeats. Previously we identified the major compounds in essential oils (% in EO) of FC fruits to be d-limonene (51.24), gamma-terpenene (33.71), alpha-pinene (3.40), and beta-pinene (2.88). Documented evidence on its insulin secretion characteristics is still lacking. In parallel to compositional analysis, we performed in vivo the safety, hypoglycemic, and antidiabetic tests in Sprague-Dawley-SPF rats and Wistar DIO rats respectively. By kinetic analysis on the hypoglycemic patterns of the intraperitoneal glucose tolerance (IPGTT) and the insulin-glucose tolerance tests (IGTT), its insulin secretagogue effect was confirmed. In conclusion, FC fruits that concomitantly possess insulin secretagogue and slimming effects would be very beneficial to type 2 diabetes mellitus patients.
    Relation: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 57(19):8812-8819
    Appears in Collections:[Department of Physical Therapy, Graduate Institute of Rehabilitation Science] Journal articles

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