Quercetin and Ferulic Acid Aggravate Renal Carcinoma in Long-Term Diabetic Victims

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Title:	Quercetin and Ferulic Acid Aggravate Renal Carcinoma in Long-Term Diabetic Victims
Authors:	(Hsieh CL);彭瓊琦(Chiung-Chi Peng);(Cheng YM);(Lin LY);(Ker YB);(Chang CH);(Chen KC);(Peng RY)
Contributors:	健康照護學院物理治療學系
Keywords:	Quercetin;renal carcimoma;streptozotocin;diabetes mellitus
Date:	2010-07
Issue Date:	2010-09-23 19:54:44 (UTC+8)
Abstract:	Many phytoantioxidants have therapeutic drawbacks due to their potent prooxidant bioactivity. It is hypothesized that phytoantioxidants (PAO) are beneficial only to the early-stage diabetes mellitus (DM) and will become ineffective once renopathy occurs. Gallic acid, rutin, EGCG, ferulic acid (FA), and quercetin were tried on the streptozotocin (STZ)-induced DM rat model for a 28 week experimental period. All of these PAO were shown to be ineffective for hypoglycemic action. The incidence of cataract (50%), injured glomerules, and renal cell carcinoma (RCC) was very common, among which the most severely affected involved the quercetin- and the FA-treated groups. The tumorigenicity of ferulic acid is still unclear. However, for quercetin, this can be attributted to (i) the prooxidant effect, (ii) the insulin−secretagogue bioactivity, and (iii) the competitive and noncompetitive inhibition on the O-methyltransferase to enhance the estradiol-induced tumorigenesis. Conclusively, quercetin and FA are able to aggravate, if not induce, nephrocarcinoma. It is time to reevaluate the tumorigenic detrimental effect of PAO, especially those exhibiting prooxidant bioactivity.
Relation:	Quercetin and Ferulic Acid Aggravate Renal Carcinoma in Long-Term Diabetic Victims JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Appears in Collections:	[Department of Physical Therapy, Graduate Institute of Rehabilitation Science] Journal articles

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