Computer Simulation of 3D Temperature and Power Distributions in Tissue with a Countercurrent Blood Vessels Network during Hyperthermia

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 生物醫學影像暨放射科學學系暨碩生班 > 期刊論文 > Item 310903500/28388

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题名:	Computer Simulation of 3D Temperature and Power Distributions in Tissue with a Countercurrent Blood Vessels Network during Hyperthermia
作者:	(HW Huang)、施子卿(Tzu-Ching Shih)、(CT Liauh)、(TL Horng)
贡献者:	健康照護學院生物醫學影像暨放射科學學系
关键词:	Hyperthermia;High Intensity Focused Ultrasound HIFU;Optimization Power;Thermally Significant Vessels
日期:	2009-10
上传时间:	2010-09-23 19:52:23 (UTC+8)
摘要:	A countercurrent blood vessel network (CBVN) model for calculating tissue temperatures has been developed for studying optimized hyperthermia cancer treatment. This type of model represents a more fundamental approach to modeling temperatures in tissue than do the generally used approximate equations such as the Pennes' bio-heat transfer equation (BHTE) or effective thermal conductivity equations. The 3-D temperature distributions are obtained by solving the conduction equation in the tissue and the convective energy equation with specified Nusselt number in the vessels. This study uses an optimization scheme to investigate the impact of thermally significant blood vessels during hyperthermia cancer treatment. The optimization scheme used here is adjusting power based on the local temperature in the treated region in an attempt to reach the ideal therapeutic temperature of 43℃. The scheme can be used (or adapted) in a non-invasive power supply application such as high-intensity focused ultrasound (HIFU). Results show that first, a large amount of thermal absorbed power is focused on the locations near (or in) blood vessels and/or dense vessels in the treated tumor region during hyperthermia treatment as mass flow rates contribute cooling effects from vessels to tissues. Second, veins also play a significant role of affecting temperature distributions in the treated region and need to be taken into consideration.
關聯:	Journal of Medical and Biological Engineering 29(5):252-258
显示于类别:	[生物醫學影像暨放射科學學系暨碩生班] 期刊論文

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