Immunomodulation of Bu-Zhong-Yi-Qi-Tang on In vitro granulocyte colony-stimulating-factor and tumor necrosis factor-a production by peripheral blood mononuclear cells

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Title:	Immunomodulation of Bu-Zhong-Yi-Qi-Tang on In vitro granulocyte colony-stimulating-factor and tumor necrosis factor-a production by peripheral blood mononuclear cells
Authors:	高尚德(Shung-Te Kao);(Shih-Liang Yang);(Chang-Chi Hsieh);(Mei-Do Yan);(Ting-Fu Wang);(Jaung-Geng Lin)
Contributors:	中醫學院中醫學系學士班中醫內科學科;中國附醫中醫內科
Keywords:	Bu-Zhong-Yi-Qi-Tang;Hepatocellular carcinoma;Granulocyte colony-stimulating-factor;and Tumor necrosis factor-α
Date:	2000
Issue Date:	2009-08-20 17:56:59 (UTC+8)
Abstract:	Bu-Zhong-Yi-Qi-Tang (BZYQT) is a Chinese medicine, and has been used for the treatment of hepatocellular carcinoma (HCC) patients. At present, we still do not fully understand the effects of BZYQT on the cellular physiology. Present in vitro study demonstrated that BZYQT is capable of increasing granulocyte colony-stimulating-factor (G-CSF) and tumor necrosis factor-a (TNF-α) production by peripheral blood mononuclear cells (PBMC) in healthy volunteers and patients with HCC. The productions of G-CSF and TNF-α by PBMC of volunteers were significantly stimulated by more than 125 μg/ml of BZYQT. G-CSF levels stimulated by PBMC of healthy volunteers were higher than in PBMC of the HCC patients when more than 625 μg/ml of BZYQT was administrated. The reason may be due to the impaired immunologic reactivity of mononuclear cells in HCC patients. However, the production levels of TNF-α in HCC patients can be stimulated to levels as high as those in healthy volunteers. When adding high concentration (3.125 mg/ml) of BZYQT to the cultured PBMC, the increments of G-CSF and TNF-α production decreased although there were no obvious changes in the number of metabolic active PBMC changed. TNF-α and G-CSF are known to play important roles in the biological defensive mechanism. These findings show that BZYQT is a unique formula for the stimulation of PBMC to produce G-CSF and TNF-α. Administration of BZYQT may be beneficial for patients with HCC to modulate these cytokines.
Relation:	IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 22(4):711~720
Appears in Collections:	[School of Chinese Medicine] Journal articles

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