p21 gene codon 31 arginine/serine polymorphism: Non-association with endometriosis

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 中醫學院 > 中醫學系暨碩博班 > 期刊論文 > Item 310903500/2793

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题名:	p21 gene codon 31 arginine/serine polymorphism: Non-association with endometriosis
作者:	謝耀元*;蔡輔仁(Fuu-Jen Tsai);張其真(Chang CC);陳汶吉(Chen Wen-Chi);蔡長海(Chang-Hai Tsai);蔡鴻德(Tsai HD);林正介(Cheng-Chieh Lin)
贡献者:	中醫學院中醫學系學士班中醫內科學科
关键词:	codon 31 polymorphism of p21;endometriosis;polymorphism;p21;single nucleotide polymorphism
日期:	2001
上传时间:	2009-08-20 17:56:41 (UTC+8)
摘要:	p21, an important regulator of the cell cycle, acts as a mediator of the growth-suppressing and -promoting functions of p53. We aimed to investigate the association between codon 31 polymorphisms of p21 gene and endometriosis. Women were divided into two groups: endometriosis (n = 102) and nonendometriosis (n = 119). The gene polymorphism for p21 codon 31 involved a base change from AGC to AGA and amino acid changes from serine (Ser) to arginine (Arg). Polymorphisms (Ser homozygotes, heterozygotes, Arg homozygotes) between both groups were detected and compared. Associations between the endometriosis and polymorphisms were evaluated. The results revealed that the distributions of different p21 polymorphisms in both groups were nonsignificantly different. The proportions of Ser homozygote/heterozygote/Arg homozygote in endometriosis and nonendometriois populations were 26.5/48.0/25.5% and 17.6/50.4/31.9%, respectively. We concluded the noncorrelation between the endometriosis and the p21 codon 31 polymorphism. p21 gene codon 31 arginine/serine polymorphism is not a useful marker for prediction of endometriosis susceptibility. J. Clin. Lab. Anal. 15:184-187,
關聯:	JOURNAL OF CLINICAL LABORATORY ANALYSIS15(4):184~187
显示于类别:	[中醫學系暨碩博班] 期刊論文

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