Association of interleukin-18 gene polymorphisms with calcium oxalate kidney stone disease

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Title:	Association of interleukin-18 gene polymorphisms with calcium oxalate kidney stone disease
Authors:	賴光啟(Kuang-Chi Lai);林維勇(Wei-Yong Lin);文寄銘(Kee-Ming Man);(Chou-Haung Tsai);陳慧毅(Huey-Yi Chen);蔡輔仁(Fuu-Jen Tsai);陳方周(Fun-jou Chen);陳幸宜(Hsin-Yi Chen);劉心萍(Hsin-Ping Liu);何宗融(Tsung-Jung Ho);(Po-Hsun Huang);(Po-Len Liu);(Feng-Yen Lin);沈瑞隆(Jui-Lung Shen);(Jung-Tung Liu);陳永祥(Yung-Hsiang Chen)陳汶吉(Chen, Wen-Chi)*
Contributors:	中醫學院中西醫結合研究所
Date:	2010-02
Issue Date:	2010-09-23 18:58:13 (UTC+8)
Abstract:	Objective. The interleukin-18 (IL-18) encoding gene has three common single-nucleotide polymorphisms at –607C/A, –137G/C and +105A/C, which have been reported to be associated with several diseases. The aim of this study is to test whether IL-18 polymorphisms could act as genetic markers for renal stone disease. Material and methods. A control group of 104 healthy subjects, and 272 patients with recurrent calcium oxalate stones were examined. Polymerase chain reaction-based restriction endonuclease analysis was used to detect IL-18 polymorphisms. Results. The patient and control groups differed significantly in genotypic expression of the IL-18 +105A/C polymorphism. The prevalence of the A/C + C/C genotypes in the patients was higher than that in the controls. The allelic frequency of IL-18 +105A/C differed significantly between the patients and the controls. The odds ratio (OR) of the A/C heterozygote of IL-18 +105A/C associated with urolithiasis was 2.772. The OR of the A/C + C/C genotypes of IL-18 +105A/C associated with urolithiasis was 3.097. The OR per copy of the C allele of IL-18 +105A/C associated with urolithiasis was 4.143. There were also significant differences in the prevalence of genotype IL-18 –137G/C polymorphisms between the patients and controls. The distribution of the G/G homozygote in the patients was higher than that in the controls. There was no significant difference in genotype and allelic frequency at the IL-18 –607C/A polymorphism between patients and control subjects. Conclusion. The results indicate that IL-18 +105A/C polymorphisms may play a role in the development of urolithiasis.
Relation:	Scandinavian Journal of Urology and Nephrology, 2010; 44: 20–26
Appears in Collections:	[Graduate Institute of Integrated Medicine] Journal articles

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