HLA-E gene polymorphism associated with susceptibility to kawasaki disease and formation of coronary artery aneurysms

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Title:	HLA-E gene polymorphism associated with susceptibility to kawasaki disease and formation of coronary artery aneurysms
Authors:	林應如(Ying-Ju Lin);萬磊(Lei Wan);鄔哲源;許晉銓(Jinn-Chyuan Sheu);林振文(Lin Cheng Wen);藍郁青(Yu-Ching Lan);賴志河(Chih-Ho Lai);洪千惠(CH Hung);蔡育勳(Yuhsin Tsai);蔡長海(Chang-Hai Tsai);林亭旭(Ting-Hsu Lin);林昭庚(Jaung-Geng Lin);薛凱中(Kai-Chung Hsueh);黃佑民(Yu-Min Huang);張正成(Jeng-Sheng Chang);蔡輔仁(Fuu-Jen Tsai)
Contributors:	中醫學院中國醫學研究所;中國附醫醫學研究部遺傳中心
Keywords:	China Medical University;Grant Number: CMU95-142;China Medical University Hospital;Grant Number: DMR-96-110;National Science Council, Taiwan;Grant Number: NSC94-2320-B-039-042, National Genotyping Center grant NSC95-3112-B-001-011;National Science and Technology Program for Genomic Medicine;Academia Sinica Genomic Medicine Multicenter Study
Date:	2009-02
Issue Date:	2009-08-20 17:48:16 (UTC+8)
Abstract:	Objective Kawasaki disease (KD) is a pediatric systemic vasculitis of unknown cause for which a genetic influence is supposed. The purpose of this study was to identify possible genetic variants in the major histocompatibility complex (MHC) region that are associated with KD and the development of coronary artery aneurysms (CAAs) in a Taiwanese population. Methods The 168 genetic variants covering the MHC locus were analyzed in an association study of a Taiwanese cohort of 93 KD patients and 680 unrelated healthy children matched for sex and age with the study patients. Results Eleven single-nucleotide polymorphisms (SNPs) were associated with the occurrence of KD. The SNP located at the 3-untranslated region of HLA-E (rs2844724) was highly associated (P < 1 × 10-7). In addition, the frequency of the C allele was higher in KD patients without CAAs than in controls (P < 0.001) due to a significantly increased frequency of the CC and CT genotypes. Plasma levels of soluble HLA-E were significantly higher in KD patients than in controls regardless of the presence of CAAs. Furthermore, there was a trend toward higher plasma levels of soluble HLA-E in KD patients with the CT and TT genotypes of the HLA-E gene polymorphism. Conclusion Our results suggest that the HLA-E gene polymorphism may play a role in the pathogenesis of KD.
Relation:	ARTHRITIS AND RHEUMATISM60(2):604~610
Appears in Collections:	[Graduate Institute of Chinese Medical Science] Journal articles

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