Platelet aggregation inhibitor from Murraya euchrestifolia

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Title:	Platelet aggregation inhibitor from Murraya euchrestifolia
Authors:	Wu, TS;Chan, YY;Liou, MJ;Lin, FW;Shi, LS;Chen, KT
Contributors:	藥學院藥化所 Natl Cheng Kung Univ, Dept Chem, Tainan 70101, Taiwan;China Med Coll, Grad Inst Pharmaceut Chem, Taichung, Taiwan;Taipei Med Coll, Grad Inst Pharmaceut Sci, Taipei, Taiwan
Date:	1998
Issue Date:	2010-09-20 14:03:55 (UTC+8)
Publisher:	JOHN WILEY & SONS LTD
Abstract:	Twenty-three carbazole alkaloids, murrayafoline-A (1), 3-methyl-carbazole (2), murrayanine (3), mukoeic acid (4), murrayazolidine (5), bicyclomahanimbine (6), murrayamine-A (10), -D (13), -E (14), -F (15), -I (16), -J (17), -K (18), -M (7), -N (19), murrayazoline (8), girinimbine (9), mahanimbine (11), (+)-mahanine (12), isomahanine (20), murrafoline-A (21), -B (22) and bismurrayafoline-A (23) and a triterpenoid, friedelin together with p-sitosterol were isolated and characterized from the leaves and root bark of M. euchrestifolia. Their structures were elucidated by spectroscopic analyses and/or direct comparison with authentic samples. The isolated carbazole alkaloids 1-12 were subjected to evaluation for antiplatelet aggregation activity and vasorelaxing effect. Most of the isolated carbazole alkaloids showed potent inhibitory, activity on rabbit platelet aggregation induced by arachidonic acid (100 mu M), collagen (10 mu g/mL) and PAF (2 ng/mL). Only murrayafoline-A (1) showed inhibition of tonic contraction induced by K+ (80 mM) + Ca2+ (1.9 mM). Compounds 1, 7 and 12 showed the promotion of the platelet aggregation or lysis at high dose. In contrast, they also exhibited antiplatelet aggregation activity at low concentration. This result could continue the philosophy of use in Chinese medicine, in that the dose variation in a prescription produced different, promotive or inhibitive, effects on therapy. (C) 1998 John Wiley & Sons, Ltd.
Relation:	PHYTOTHERAPY RESEARCH 12():S80-S82
Appears in Collections:	[Graduate Institute of Pharmaceutical Chemistry] Proceedings

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