中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/27381
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    题名: THE ANTIALLERGIC ACTIVITIES OF SYNTHETIC ACROPHYLLINE AND ACROPHYLLIDINE
    作者: HUANG, AC;LIN, TP;KUO, SC;WANG, JP
    贡献者: 藥學院藥化所
    CHINA MED COLL,GRAD INST PHARMACEUT CHEM,TAICHUNG,TAIWAN;NATL RES INST CHINESE MED,TAIPEI,TAIWAN;TAICHUNG VET GEN HOSP,DEPT MED RES,TAICHUNG,TAIWAN
    日期: 1995
    上传时间: 2010-09-20 14:03:53 (UTC+8)
    出版者: AMER SOC PHARMACOGNOSY
    摘要: The antiallergic activities of synthetic acrophylline [1] and acrophyllidine [2] have been demonstrated. Both compounds 1 and 2 at 30 mu mol/kg reduced the plasma leakage in mouse ear in a passive cutaneous anaphylactic (PCA) reaction. In addition, compound 1 suppressed mast cell degranulation in a dose-dependent manner, while compound 2 at 100 mu M produced no significant inhibition of the release of preformed inflammatory mediators. These results suggest that the antiallergic effect of compound I probably occurs through the suppression of mast cell degranulation, and that of compound 2 by protection of the vasculature against challenge by mediators of inflammation.
    關聯: JOURNAL OF NATURAL PRODUCTS-LLOYDIA 58(1):117-120
    显示于类别:[藥物化學研究所] 會議論文

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