HYPOTENSIVE AND BRADYCARDIAC EFFECTS OF DL-TETRAHYDROPALMATINE MEDIATED BY DECREASE IN HYPOTHALAMIC SEROTONIN RELEASE IN THE RAT

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題名:	HYPOTENSIVE AND BRADYCARDIAC EFFECTS OF DL-TETRAHYDROPALMATINE MEDIATED BY DECREASE IN HYPOTHALAMIC SEROTONIN RELEASE IN THE RAT
作者:	CHUEH, FY;HSIEH, MT;CHEN, CF;LIN, MT
貢獻者:	藥學院中藥所 NATL CHENG KUNG UNIV,COLL MED,DEPT PHYSIOL,TAINAN,TAIWAN;CHINA MED COLL,INST CHINESE PHARMACEUT SCI,TAICHUNG,TAIWAN;NATL RES INST CHINESE MED,TAIPEI,TAIWAN
日期:	1995
上傳時間:	2010-09-20 14:03:02 (UTC+8)
出版者:	JAPANESE PHARMACOLOGICAL SOC
摘要:	In anesthetized rats, intravenous administration of dl-tetrahydropalmatine (dl-THP, 1-10 mg/kg) elicited proportional hypotension, bradycardia and decreases in hypothalamic serotonin (5-HT) release (measured by carbon-fiber electrodes in combination with voltammetry). In addition, postsynaptic blockade of 5-HT2 receptors with cyproheptadine (2-5 mg/kg, i.v.) or ketanserin (2-5 mg/kg, i.v.) produced both hypotension and bradycardia, while stimulation of 5-HT2 receptors with 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) (10-250 mg/kg, i.v.) produced both hypertension and tachycardia. The dl-THP-induced hypotension and bradycardia could be reversed by DOI treatment. The data indicate that dl-THP decreases both arterial pressure and heart rate through a serotonergic release process in the hypothalamus.
關聯:	JAPANESE JOURNAL OF PHARMACOLOGY 69(2):177-180
顯示於類別:	[中國藥學研究所(已停用)] 會議論文

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