VASORELAXANTS FROM CHINESE HERBS, EMODIN AND SCOPARONE, POSSESS IMMUNOSUPPRESSIVE PROPERTIES

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Title:	VASORELAXANTS FROM CHINESE HERBS, EMODIN AND SCOPARONE, POSSESS IMMUNOSUPPRESSIVE PROPERTIES
Authors:	HUANG, HC;CHU, SH;CHAO, PDL
Contributors:	醫學院醫學系藥理學科 NATL TAIWAN UNIV,COLL MED,DEPT SURG,TAIPEI,TAIWAN;CHINA MED COLL,DEPT PHARM,TAICHUNG,TAIWAN
Date:	1991
Issue Date:	2010-09-20 14:01:32 (UTC+8)
Publisher:	ELSEVIER SCIENCE BV
Abstract:	Emodin and scoparone, the active principles isolated from Polygonum multiflorum and Artemisia scoparia, respectively, both exhibit vasorelaxant and immunosuppressive effects. Emodin (10(-6)-3 x 10(-5) M) and scoparone (10(-6)-3 x 10(-5) M) dose dependently relaxed rat thoracic aortic rings precontracted with phenylephrine. Emodin (3 x 10(-7)-10(-4) M) and scoparone (10(-6)-3 x 10(-4) M) also dose dependently suppressed the responses of human mononuclear cells to phytohemagglutinin and mixed lymphocyte reaction. These compounds may be useful as new templates for the development of better immunosuppressive agents with vasorelaxant actions for use against transplantation rejection and autoimmune disease.
Relation:	EUROPEAN JOURNAL OF PHARMACOLOGY 198(2月3日):211-213
Appears in Collections:	[School of Medicine] Proceedings

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