In vivo magnetic resonance (MR) study of fatty liver: Importance of intracellular ultrastructural alteration for MR tissue parameters change

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Title:	In vivo magnetic resonance (MR) study of fatty liver: Importance of intracellular ultrastructural alteration for MR tissue parameters change
Authors:	Chai, JW;Lin, YC;Chen, JH;Wu, CC;Lee, CP;Chu, WC;Lee, SK
Contributors:	附設醫院放射線部 China Med Coll Hosp, Dept Radiol, 2 Yuh Der Rd, Taichung 404, Taiwan
Date:	2001
Issue Date:	2010-09-20 13:56:08 (UTC+8)
Publisher:	JOHN WILEY & SONS INC
Abstract:	Fatty liver Is thought to have a shorter T1 relaxation time than normal liver tissue, due to the accumulation of triglyceride. Previous studies regarding T1 and T2 relaxation times, however, show widely different results. In order to elucidate the mechanism responsible for the changes and diversity of relaxation times in fatty liver, we created two animal models in 14 rabbits, one acute form (N = 6) and the other chronic form (N = 8). Four rabbits were taken as a control group. Tissue relaxation times and the magnetization transfer (MT) effect of the liver tissue in these two models were measured. The results were correlated with biochemical analysis of water and fat content and histological examination, including findings in fight microscopy and electron microscopy. Although the fatty ratio in both forms of fatty liver was similar, their tissue relaxation rate and MT effect were significantly different. The acute form showed prolongation of both T1 and T2 relaxation times (512 +/- 51 msec vs. 710 +/- 95 msec and 39 +/- 1.8 msec vs. 48 +/- 3.7 msec, respectively) and a decrease of the NIT effect (50 +/- 5.1% vs. 38 +/- 6.3%), compared to those of the control group and preinduction liver. The chronic form showed shorter T1 and T2 values (526 +/- 36 msec vs. 406 +/- 56 msec and 36 +/- 1.6 msec vs. 33 +/- 2.3 msec, respectively) and a stronger NIT effect (21 +/- 0.9% vs. 26 +/- 2.3%). In acute form fatty liver, electron microscopic examination revealed dramatic subcellular changes, such as vesicular transformation, a markedly increased amount of smooth endoplasmic reticulum (SER), and disruption of the crista. These changes were not found In the chronic form fatty liver. From this study, we concluded that the ultrastructural alteration in the subcellular organelles of hepatocyte might play a crucial role for the chameleonic presentation of MR tissue parameters in fatty liver. (C) 2001 Wiley-Liss, Inc.
Relation:	JOURNAL OF MAGNETIC RESONANCE IMAGING 14(1):35-41
Appears in Collections:	[China Medical University Hospital] Proceedings

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